19338-21-7

Basic information

• Product Name: Benzoic acid,4-methyl-, 2-benzoylhydrazide
• Synonyms: Hydrazine,1-benzoyl-2-p-toluoyl- (6CI,8CI); 4-Methylbenzoic Acid N-Benzoylhydrazide; NSC87967
• CAS NO: 19338-21-7
• Molecular Formula: C15H14 N2 O2
• Molecular Weight: 254.288
• Mol File: 19338-21-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 507.1°Cat760mmHg
• Flash Point: 205.6°C
• Density: 1.186g/cm³
• CAS DataBase Reference: Benzoic acid,4-methyl-, 2-benzoylhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid,4-methyl-, 2-benzoylhydrazide(19338-21-7)
• EPA Substance Registry System: Benzoic acid,4-methyl-, 2-benzoylhydrazide(19338-21-7)

Safety Data

• Hazardous Substances Data: 19338-21-7(Hazardous Substances Data)

Upstream product

• 106-38-7 para-bromotoluene 
• 613-94-5 benzoic acid hydrazide 
• 624-31-7 4-tolyl iodide 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 99-94-5 p-Toluic acid 
• 142273-51-6 methyl 2-(3-oxo-5-p-tolyl-2,3-dihydrofuran-2-ylidene)acetic acid 
• 155164-66-2 2-benzoyl-4,5-dichloropyridazin-3(2H)-one 
• 155164-67-3 4,5-Dichloro-2-(4-methyl-benzoyl)-2H-pyridazin-3-one 
• 3619-22-5 p-toluic hydrazide 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 16112-32-6 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole 
• 1557164-62-1 4-(5-phenyl-1,3,4-thiadiazol-2-yl)benzaldehyde 
• 1203959-20-9 2-(4-(bromomethyl)phenyl)-5-phenyl-1,3,4-thiadiazole 
• 21464-13-1 2-(4-(bromomethyl)phenyl)-5-phenyl-1,3,4-oxadiazole 
• 1156534-45-0 2-phenyl-5-p-tolyl-1,3,4-selenadiazole 
• 471910-32-4 3-(4-methylphenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 3213-95-4 3-(4-methylphenyl)-5-phenyl-1H-1,2,4-triazole 
• 80465-10-7 1-Methyl-5-phenyl-3-p-tolyl-1H-[1,2,4]triazole 
• 106-49-0 p-toluidine 
• 62-53-3 aniline 
• 1874-47-1 2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Reusable colorimetric and fluorescent chemosensors based on 1,8-naphthalimide derivatives for fluoride ion detection

Two 1, 8-naphthalimide derivatives, 2-(2-ethylhexyl)-6-(2-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzylidene)hydrazinyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (named as NAOZ) and 2-(2-ethylhexyl)-6-(2-(4-(5-phenyl-1,3,4-thiadiazol-2-yl)benzylidene)hydrazinyl)

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.

17O NMR studies of substituted 1,3,4-oxadiazoles

Three series of substituted 1,3,4-oxadiazoles were studied by 17O NMR spectroscopy. Chemical shifts values were correlated with empirical Hammett parameters as well as calculated bond lengths and chemical shielding values.