80466-79-1

Usage

Chemical Properties

White to off-white solid

InChI:InChI=1/C5H6ClNO3S/c1-3-5(11(6,8)9)4(2)10-7-3/h1-2H3

Upstream product

• 300-87-8 3,5-dimethyl-1,2-oxazole 

Downstream Products

• 17605-87-7 1-(3,5-dimethyl-isoxazole-4-sulfonyl)-3,5-dimethyl-1H-pyrazole 
• 80466-89-3 N-(4-chlorophenyl)-3,5-dimethyl-4-isoxazolesulfonamide 
• 890169-36-5 1-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-4-phenyl-1,2,3,6-tetrahydropyridine 
• 909897-15-0 methyl 4-{[2-{[(3,5-dimethylisoxazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate 
• 685544-54-1 (S)-5-[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-2-(3,5-dimethylisoxazole-4-sulfonylamino)-5-oxopentanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Development of novel NLRP3-XOD dual inhibitors for the treatment of gout

Gout is a crystalline-related arthropathy caused by the deposition of monosodium urate (MSU). Acute gouty arthritis is the most common first symptom of gout. Studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome as pattern recognition r

Convenient synthesis of novel 5-substituted 3-methylisoxazole-4- sulfonamides

A number of novel sulfonamide derivatives of 5-substituted-3- methylisoxazole were synthesized and characterized, starting from 3,5-dimethylisoxazole. Key steps include the generation of 3,5- dimethylisoxazole-4-sulfonamides followed by their reactions wi

Bispiperidines as antithrombotic agents

Novel compounds which are inhibitors of the binding of fibrinogen to the Gp IIb/IIIa platelet receptors, and which can be used therepeutically as antithrombotic agents

Process for preparing 3,5-dimethylisoxazole-4-sulphonyl chloride

By a novel process, 3,5-dimethylisoxazole-4-sulphonyl chloride is prepared by reacting 3,5-dimethylisoxazole initially with chlorosulphonic acid and then additionally with thionyl chloride at a temperature between 60° C. and 110° C.

Some Heterocyclic Sulfonyl Chlorides and Derivatives

The syntheses of 4- and 5-chlorosulfonylfuran-2-carboxylic acid (Ia,IIa), 4-chlorosulfonylfuran-2-carboxamide (Ib), 3,5-dimethylpyrazole and isoxazole-4-sulfonyl chlorides (IIa, IVa) and 2,4-dimethylthiazole-5-sulfonyl chloride (Va) are described.The sulf