80467-51-2

Upstream product

• 2199-93-1 3-Acetyl-6-bromo-chromen-2-one 
• 100-52-7 benzaldehyde 
• 22532-61-2 2-bromo-6-hydroxybenzaldehyde 
• 1761-61-1 5-bromosalicyclaldehyde 
• 848322-75-8 3-acetyl-7-bromo-2H-chromen-2-one 

Downstream Products

• 80467-66-9 1-(6-Bromo-2,2,4-triphenyl-chroman-3-yl)-3,3-diphenyl-propan-1-one 
• 80467-67-0 1-[6-Bromo-2,2,4-tris-(4-methoxy-phenyl)-chroman-3-yl]-3-(4-methoxy-phenyl)-3-phenyl-propan-1-one 
• 80467-64-7 6-Bromo-3-[3-(3,4-dimethyl-phenyl)-3-phenyl-propionyl]-chroman-2-one 
• 80467-63-6 6-Bromo-3-[3-(2,4-dimethyl-phenyl)-3-phenyl-propionyl]-chroman-2-one 
• 80467-70-5 4-Acetyl-3-benzylamino-5-phenyl-cyclohex-3-enone 
• 80467-71-6 4-Acetyl-3-methylamino-5-phenyl-cyclohex-3-enone 
• 80467-73-8 2,3-dihydro-2-benzofuryl phenyl ketone 
• 80467-69-2 4-Benzoyl-3-methylamino-5-phenyl-cyclohex-3-enone 
• 80467-62-5 6-Bromo-3-{(E)-3-phenyl-1-[(E)-p-tolylimino]-allyl}-chromen-2-one 
• 80467-65-8 6-Bromo-3-[3-(4-isopropyl-phenyl)-3-phenyl-propionyl]-chroman-2-one 
• 80467-72-7 4-Acetyl-5-phenyl-3-piperidin-1-yl-cyclohex-3-enone 

Relevant academic research and scientific papers

Synthesis, thermal, and biological studies of newly synthesized Cu(II) complexes with ciprofloxacin based on bromo-coumarins derivatives

The authors describe synthesis, characterization, and biological evaluation of Cu(II) complexes. Characterization of ligands has been carried out by elemental analysis, melting point, mass spectra, (1H & 13C) NMR, and FT-IR, while st

Multiple heating rate kinetic parameters, thermal, X-ray diffraction studies of newly synthesized octahedral copper complexes based on bromo-coumarins along with their antioxidant, anti-tubercular and antimicrobial activity evaluation

Series of new Cu(II) complexes were synthesized by classical thermal technique. The biologically potent ligands (L) were prepared by refluxing 6-brom 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. The Cu(II) complexes have been synthesized by mixing an aqueous solution of Cu(NO3)2 in 1:1 molar ratios with ethanolic bidentate ligands and Clioquinol. The structures of the ligands and their copper complexes were investigated and confirmed by the elemental analysis, FT-IR, 1H NMR, 13C NMR, mass spectral and powder X-ray diffraction studies respectively. Thermal behaviour of newly synthesized mixed ligand Cu(II) complexes were investigated by means of thermogravimetry, differential thermogravimetry, differential scanning calorimetry, electronic spectra and magnetic measurements. Dynamic scan of DSC experiments for Cu(II) complexes were taken at different heating rates (2.5-20 °C min-1). Kinetic parameters for second step degradation of all complexes obtained by Kissinger's and Ozawa's methods were in good agreement. On the basis of these studies it is clear that ligands coordinated to metal atom in a monobasic bidentate mode, by OO and ON donor system. Thus, suitable octahedral geometry for hexa-coordinated state has been suggested for the metal complexes. Both the ligands as well as its complexes have been screened for their in vitro antioxidant, anti-tubercular and antimicrobial activities. All were found to be significant potent compared to parent ligands employed for complexation.

Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents

A series of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential telomerase inhibitors were synthesized. The bioassay tests show that compound 3d exhibited potentially high activity against human gastric cancer cell SGC-7901 with IC50 value of 2.69 ± 0.60 μg/mL. All title compounds were assayed for telomerase inhibition by a modified TRAP assay, the results show that compounds 3d and 3f can strongly inhibit telomerase with IC50 values of 2.0 ± 0.07 and 1.8 ± 0.35 μM, respectively. Docking simulation was performed to position compound 3d into the telomerase (3DU6) active site to determine the probable binding model.

A facile one pot synthesis of 2-aryl-4-[2H-2-oxo-[1]benzopyran-3-yl] 2,3-dihydro and 2,5-dihydro-1,5-benzothiazepines

3-acetyl coumarins on condensation with various aromatic aldehydes in the presence of piperidine gave corresponding chalcones in a solid state under solvent free conditions. These chalcones are isolated and characterized. The insitu-formed chalcones (1) a

Reactions of 3-Acetyl-6-bromocoumarin: Synthesis of 6H-1,3-Benzoxazocine, 7H-Benzopyranoquinoline, 5H-Benzopyranopyridine, 6H-Dibenzopyran, Xanthene and Chroman Derivatives

3-Acetyl-6-bromocoumarin (I) reacts with benzaldehyde, cyclohexanone or acetophenone to give the condensation adducts II, III and IV respectively.Michael reaction of I with cyclohexanone, acetone or acetophenone in the presence of methylamine at room temp