80467-61-4Relevant academic research and scientific papers
Some new indole-coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies
Kamath, Pooja R.,Sunil, Dhanya,Ajees, A. Abdul,Pai,Das, Shubhankar
, p. 101 - 109 (2015)
Hybrid molecules have attracted attention for their improved biological activity, selectivity and lesser side effects profile, distinct from their individual components. In the quest for novel anticancer drug entities, three series of indole-coumarin hybrids - 3-(1-benzyl-1H-indol-2-yl)-2H-chromen-2-ones, 2-(2-oxo-2H-chromen-3-yl)-1H-indole-3-carbaldehydes and 2-(2-oxo-2H-chromen-3-yl)-1H-indole-3-carboxylic acids were synthesized. All the synthesized compounds were characterized by spectral techniques like IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. In silico docking studies of synthesized molecules with apoptosis related gene Bcl-2 that is recognized to play an important role in tumerogenesis were carried out. Dose-dependent cytotoxic effect of the compounds in human breast adenocarcinoma (MCF-7) and normal cell lines were assessed using MTT assay and compared with that of the standard marketed drug, Vincristine. Compound 4c had a highly lipophilic bromine substituent capable of forming halogen bond and was identified as a potent molecule both in docking as well as cytotoxicity studies. Flow cytometric cell cycle analysis of 4c exhibited apoptotic mode of cell death due to cell cycle arrest in G2/M phase. Structure activity relationship of these hybrid molecules was also studied to determine the effect of steric and electronic properties of the substituents on cell viability.
ORGANIC COMPOUND, AND ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DISPLAY DEVICE INCLUDING THE SAME
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Paragraph 0091-0094, (2020/07/07)
Discussed is an organic compound of Formula 1 and an organic light emitting diode and an OLED device including the organic compound. In the organic compound, Ar1 is a heteroaryl group comprising a nitrogen atom, and Ar2 is a C6 to C30 /su
Synthesis, Photophysical and Computational Study of Novel Coumarin-based Organic Dyes
Kumbar, Mahadev N.,Sannaikar, Madivalagouda S.,Shaikh, Saba Kauser J.,Kamble, Atulkumar A.,Wari, Manjunath N.,Inamdar, Sanjeev R.,Qiao, Qiquan,Revanna, Bhavya N.,Madegowda, Mahendra,Dasappa, Jagadeesh P.,Kamble, Ravindra R.
, p. 261 - 276 (2018/02/06)
A series of novel coumarin pyrazoline moieties combined with tetrazoles, 3-(1-phenyl-4-(1H-tetrazol-5-yl)-1H-pyrazol-3-yl)-2H-chromen-2-one, 6-chloro-3-(1-phenyl-4-(1H-tetrazol-5-yl)-1H-pyrazol-3-yl)-2H-chromen-2-one, 6-bromo-3-(1-phenyl-4-(1H-tetrazol-5-
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors
Grover, Jagdeep,Kumar, Vivek,Sobhia, M. Elizabeth,Jachak, Sanjay M.
supporting information, p. 4638 - 4642 (2015/01/09)
As a part of our continued efforts to discover new COX inhibitors, a series of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones were synthesized and evaluated for in vitro COX inhibitory potential. Within this series, seven compounds (3a-d, 3h, 3k and 3
Synthesis and antimicrobial activity of coumarin pyrazole pyrimidine 2,4,6(1H,3H,5H)triones and thioxopyrimidine4,6(1H,5H)diones
Vijaya Laxmi,Suresh Kuarm,Rajitha
, p. 768 - 774 (2013/04/10)
A series of 5-((3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazol-4-yl) methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (4a-f) and dihydro-5-((3-(2-oxo-2H- chromen-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H) -dione (5a-f) derivatives w
X-ray supramolecular structure, NMR spectroscopy and synthesis of 3-methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-ones formed by the unexpected cyclization of 3-[1-(phenylhydrazono)ethyl]-chromen-2-ones
Padilla-Martinez, Itzia I.,Flores-Larios, Irma Y.,Garcia-Baez, Efren V.,Gonzalez, Jorge,Cruz, Alejandro,Martinez-Martinez, Francisco J.
experimental part, p. 915 - 932 (2011/04/18)
The molecular structures of nine 3-methyl-1-phenyl-1H-chromeno[4,3-c] pyrazol-4-one isomers, obtained by the oxidative cyclization of the corresponding 1-phenylhydrazono chromen-2-ones with copper acetate as catalyst, are reported. The molecular and supra
Reactions of 3-Acetyl-6-bromocoumarin: Synthesis of 6H-1,3-Benzoxazocine, 7H-Benzopyranoquinoline, 5H-Benzopyranopyridine, 6H-Dibenzopyran, Xanthene and Chroman Derivatives
Younes, M. El-Garby,El-Kady, M.,Essawy, A. I.,Mohamed, A. Y.
, p. 747 - 750 (2007/10/02)
3-Acetyl-6-bromocoumarin (I) reacts with benzaldehyde, cyclohexanone or acetophenone to give the condensation adducts II, III and IV respectively.Michael reaction of I with cyclohexanone, acetone or acetophenone in the presence of methylamine at room temp
