8048-52-0 Usage
Uses
Used in Biomedical Research:
Acriflavine is used as a fluorescent label for high molecular weight RNA, allowing researchers to visualize and study the structure, function, and interactions of RNA molecules within cells. This application is particularly useful in understanding the role of RNA in various cellular processes and diseases.
Used in Diagnostic Applications:
Acriflavine is used in dual fluorescence analysis for the simultaneous detection and quantification of cellular DNA and protein. This technique enables researchers to assess the integrity and quantity of these biomolecules, which can be crucial for diagnosing certain genetic disorders or monitoring the progression of diseases.
Used in Antimicrobial Therapy:
Due to its broad-spectrum antimicrobial activity, Acriflavine has been used as a therapeutic agent in the treatment of various bacterial, fungal, and viral infections. Its ability to bind to nucleic acids and disrupt their function makes it an effective agent against a wide range of pathogens.
Used in Textile Industry:
Acriflavine is also used in the textile industry as a dye for coloring fabrics. Its strong color and fluorescence properties make it suitable for creating vibrant and visually appealing textiles.
Safety Profile
Poison by
subcutaneous route. Questionable
carcinogen with experimental tumorigenic
data. Human mutation data reported. A
topical antiseptic used in the treatment of
gonorrhea. When heated to decomposition
it emits very toxic fumes of NOx and Cl-.
See also 3,6-DIAMINO-10
METHYLACRIDINIUM CHLORIDE.
Purification Methods
Treat acriflavin twice with freshly precipitated AgOH to remove proflavine, then recrystallise it from absolute methanol [Wen & Hsu J Phys Chem 66 1353 1962]. [Beilstein 22 III/IV 218.]
Check Digit Verification of cas no
The CAS Registry Mumber 8048-52-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 8,0,4 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 8048-52:
(6*8)+(5*0)+(4*4)+(3*8)+(2*5)+(1*2)=100
100 % 10 = 0
So 8048-52-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H13N3.C13H11N3.ClH/c1-17-13-6-5-10(15)7-9(13)8-11-12(16)3-2-4-14(11)17;14-9-4-5-12-8(6-9)7-10-11(15)2-1-3-13(10)16-12;/h2-8,16H,15H2,1H3;1-7H,14-15H2;1H
