80488-98-8

Upstream product

• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 109-06-8 α-picoline 
• 18523-22-3 2,3'-dibromoacetophenone 

Downstream Products

• 77832-44-1 [2-(3-Bromo-phenyl)-indolizin-3-yl]-(3,5-dibromo-4-hydroxy-phenyl)-methanone 
• 88273-88-5 Toluene-4-sulfonic acid 4-[2-(3-bromo-phenyl)-indolizine-3-carbonyl]-2-chloro-phenyl ester 
• 88273-83-0 Toluene-4-sulfonic acid 2-bromo-4-[2-(3-bromo-phenyl)-indolizine-3-carbonyl]-phenyl ester 
• 77823-42-8 [2-(3-Bromo-phenyl)-indolizin-3-yl]-(3-chloro-4-hydroxy-phenyl)-methanone 
• 77823-32-6 (3-Bromo-4-hydroxy-phenyl)-[2-(3-bromo-phenyl)-indolizin-3-yl]-methanone 
• 79285-90-8 [3-Bromo-4-(3-dipropylamino-propoxy)-phenyl]-[2-(3-bromo-phenyl)-indolizin-3-yl]-methanone; compound with oxalic acid 
• 79286-17-2 [2-(3-Bromo-phenyl)-indolizin-3-yl]-[3-chloro-4-(3-dipropylamino-propoxy)-phenyl]-methanone; compound with oxalic acid 
• 79286-16-1 [2-(3-Bromo-phenyl)-indolizin-3-yl]-[3-chloro-4-(3-dibutylamino-propoxy)-phenyl]-methanone; compound with oxalic acid 

Relevant academic research and scientific papers

A visible-light-induced intermolecular [3 + 2] alkenylation-cyclization strategy: Metal-free construction of pyrrolo[2,1,5-cd] indolizine rings

A simple and efficient visible-light-induced intermolecular [3 + 2] alkenylation-cyclization process has been developed. This reaction provided an unprecedented metal-free double C(sp2)-H bond oxidation coupling of indolizines with electron-deficient alkenes. Through this cascade reaction, a series of pyrrolo[2,1,5-cd]indolizine derivatives with a large π-system were synthesized. Furthermore, this approach features easily available starting materials, good functional group tolerance, step-economy, high efficiency and mild conditions.

Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

Oxidation potential-guided electrochemical radical-radical cross-coupling reactions between N-heteroarenes and sodium sulfinates have been established. Thus, simple cyclic voltammetry measurement of substrates predicts the likelihood of successful radical-radical coupling reactions, allowing the simple and direct synthetic access to 3-sulfonylated imidazopyridines and indolizines. The developed electrochemical radical-radical cross-coupling reactions to sulfonylated N-heteroarenes boast the green synthetic nature of the reactions that are oxidant- and metal-free.

Mechanochemical Synthesis of 1,2-Diketoindolizine Derivatives from Indolizines and Epoxides Using Piezoelectric Materials

A simple and efficient mechanochemical-induced approach for the synthesis of 1,2-diketoindolizine derivatives has been developed. BaTiO3 was used as the piezoelectric material in this transformation. This method features no usage of solvent, simple experimental operation, scalable potential, and high conversion efficiency, which make it attractive and practical.

Visible-Light-Induced Regioselective Dicarbonylation of Indolizines with Oxoaldehydes via Direct C-H Functionalization

A metal-free system for regioselective dehydrogenative cross-couplings between indolizines and oxoaldehydes catalyzed by visible light under mild conditions has been described. As an atom economical and eco-friendly protocol, the reaction proceeds in good yields using inexpensive, readily available visible-light sources and the environmentally friendly oxidant oxygen. Various valuable 1,2-dicarbonyl derivatives attached to an indolizine core were easily accessed by the direct dicarbonylation of the sp2 C-H bond.