8049-47-6

Basic information

• Product Name: Pancreatin
• Synonyms: beefviokase;diastasevera;ilozyme;intrazyme;pancrex-v;pankreon;pankrotanon;panteric
• CAS NO: 8049-47-6
• Molecular Weight: 0
• EINECS: 232-468-9
• Product Categories: Enzyme;Inhibitors
• Mol File: 8049-47-6.mol
• Article Data: 0

Chemical Properties

• Appearance: beige/powder
• Density: 1.4-1.52
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: −20°C
• Solubility: Soluble or partly soluble in water forming a slightly turbid solution; practically insoluble in ethanol (96%) and in ether .
• Water Solubility: Soluble in water. Insoluble in alcohol and ether.
• Stability: Stable. Incompatible with alcohols, strong acids.
• Merck: 13,7075
• CAS DataBase Reference: Pancreatin(CAS DataBase Reference)
• NIST Chemistry Reference: Pancreatin(8049-47-6)
• EPA Substance Registry System: Pancreatin(8049-47-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-42-42/43
• Safety Statements: 22-24-26-36/37-37/39
• WGK Germany: 1
• RTECS: RT9033000
• F: 3-10
• TSCA: Yes
• Hazardous Substances Data: 8049-47-6(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 8049-47-6 differently. You can refer to the following data:
1. cream powder
2. Pancreatin is a yellowish to cream-colored, amorphous powder with a strong odor. Slightly soluble in water. Hazard Identification (based on NFPA-704 M Rating System): Health 1, Flammability 1, Reactivity 0. Sparingly soluble in water.

Uses

Different sources of media describe the Uses of 8049-47-6 differently. You can refer to the following data:
1. Enzyme (digestant adjunct).
2. Pancreatin from porcine pancreas has been used:for a study to assess the treatment of steatorrhea by lipase supplementation therapyfor a study to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitisto safely and effectively remove formalin-fixed tissues from arterial grafts without causing structural damage and loss in fiber integrity to assess cleavage by digestive enzymes. for in vitro digestibility analysis and to test the sensitivities of cellulolytic bacteria inhibitors. along with amyloglucosidase for the in vitro digestion of starch in food samples.
3. Hydrolyzes starch into dextrins and sugar Pancreatin from porcine pancreas is used in the treatment of steatorrhea by lipase supplementation therapy and for pancreatic diabetes. It is also used in the removal of formalin-fixed tissues from arterial grafts without causing damage in fiber integrity. Further, it finds uses in contact lenses. In addition to this, it hydrolyzes starch into dextrins and sugar. It is also used to treat conditions responsible for deficiency in pancreatic secretions, such as surgical pancreatectomy, pancreatitis and cystic fibrosis.

Brand name

Panteric (Parke-Davis).

Biological Functions

Pancreatin is a supplement that can result in decreased food intake. It is used for digestion, and absorption of food. Your pancreas secretes about one and one half quarts of pancreatic juice daily into the small intestine.

General Description

Pancreatin (Panteric) is a substance obtained from the fresh pancreas of the hog or the ox and contains a mixture of enzymes, principally pancreatic amylase (amylopsin), protease, and pancreatic lipase (steapsin). It converts not less than 25 times its weight of USP Potato Starch Reference Standard into soluble carbohydrates and not less than 25 times its weight of casein into proteoses. It acts best in neutral or faintly alkaline media, and excessive acid or alkali renders it inert. Pancreatin can be prepared by extracting the fresh gland with 25% alcohol or with water and subsequently precipitating with alcohol. Besides the enzymes mentioned, it contains some trypsinogen, which can be activated by intestinal enterokinase; chymotrypsinogen, which is converted by trypsin to chymotrypsin; and carboxypeptidase. Pancreatin is used largely for predigestion of food and for the preparation of hydrolysates. The value of its enzymes orally must be very small because they are digested by pepsin and acid in the stomach, although some of them may escape into the intestines without change. Even if they are protected by enteric coatings, it is doubtful they could be of great assistance in digestion.

Biochem/physiol Actions

Due to the enzymatic components such as trypsin, amylase and lipase, pancreatin hydrolyzes proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40?°C, will digest not less than 25 times its weight of casein in 60 minutes at pH7.5 at 40?°C and will release not less than 2 microequivalents of acid per min per mg pancreatin from olive oil at pH9.0 at 37?°C.

Clinical Use

#N/A

Safety Profile

Moderately toxic by subcutaneous and intraperitoneal routes.

Potential Exposure

It is an enzyme found in the pancreas and is used in medicines and in treating leather and textiles.

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

Pharmacokinetic data are not available as the enzymes act locally in the gastrointestinal tract. After exerting their action, the enzymes are digested themselves in the intestine.

Incompatibilities

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols.