80495-38-1Relevant articles and documents
New approaches towards monoamino polyglycerol dendrons and dendritic triblock amphiphiles
Wyszogrodzka, Monika,Moews, Katrin,Kamlage, Stefan,Wodzinska, Joanna,Plietker, Bernd,Haag, Rainer
, p. 53 - 63 (2008/09/17)
In order to improve the water solubility of nonpolar compounds such as drugs or dyes, new amphiphilic molecules are needed. In this paper we describe a new class of triblock amphiphiles that we have synthesized by a straightforward convergent approach. These amphiphiles each consist of a nonpolar biphenyl core and a polar shell based on various generations of monoamino polyglycerol dendrons, coupled to the core through amide linkages (1). For the synthesis of these monoamino dendrons we applied a simple iterative two-step process based on allylation of an alcohol group and catalytic dihydroxylation. As starting materials, D,L-serine/serinol and - in a second, similar pathway - commercially available triglycerol were used. The transport behavior of these defined triblock amphiphiles was then investigated with the nonpolar dye Nile Red in water. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.