246232-73-5

Basic information

• Product Name: 2-(N,N-Dibenzyl)-amino-1,3-propanediol
• Synonyms: 2-(N,N-Dibenzyl)-amino-1,3-propanediol;2-(DibenzylaMino)propane-1,3-diol
• CAS NO: 246232-73-5
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.35414
• Mol File: 246232-73-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 81-82 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• Boiling Point: 455.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.15±0.10(Predicted)
• CAS DataBase Reference: 2-(N,N-Dibenzyl)-amino-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N,N-Dibenzyl)-amino-1,3-propanediol(246232-73-5)
• EPA Substance Registry System: 2-(N,N-Dibenzyl)-amino-1,3-propanediol(246232-73-5)

Safety Data

• Hazardous Substances Data: 246232-73-5(Hazardous Substances Data)

Usage

General Description

2-(N,N-Dibenzyl)-amino-1,3-propanediol is a chemical compound that belongs to the class of organic compounds known as benzylamines. These are organic compounds containing a benzylamine moiety, which consists of a benzene ring substituted by an amine group. As for its structure, this compound is characterized by the presence of two benzyl groups attached to an amino group which is further connected to a 1,3-propanediol. Due to its chemical features, it may find use in various chemical reactions as an intermediate. Overall, it's specific use, properties, and toxicity could vary based and would need to be determined by further scientific research.

Upstream product

• 80495-38-1 N,N-dibenzylserine 
• 100-39-0 benzyl bromide 
• 534-03-2 serinol 

Downstream Products

• 1028208-38-9 C₂₃H₂₉NO₂ 
• 1647153-70-5 C₂₉H₄₉NO₂Si₂ 
• 1176042-41-3 N,N-dibenzyl-2,5,8,11,15,18,21,24-octaoxapentacosan-13-amine 
• 919524-45-1 N,N-dibenzyl-2,5,8,12,15,18-hexaoxa-10-nonadecanamine 

Relevant articles and documents

Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA

A number of N,N′-disubstituted perylenetetracarboxylic diimides have been reported to bind effectively to DNA that adopts G-quadruplex motifs. In some cases, this binding may actively drive the transition from single-strand DNA to the quadruplex form. The perylenediimides in the reported cases all have amine-containing side chains, which are thought to interact with the grooves of the quadruplex and help dictate the selectivity of these compounds for quadruplex versus duplex DNA. We synthesized a polyethyleneglycol-swallowtailed (PEG-tailed) perylenediimide that is water-soluble even though it is uncharged. Binding to duplex and quadruplex DNA of this perylenediimide was studied by fluorescence quenching titrations under a variety of salt conditions, and the compound's effect on quadruplex formation was studied by non-denaturing gel electrophoresis. Our results indicate that while the molecule binds to single-stranded DNA quite effectively and with selectivity, it does not drive the transition of the DNA to the tetrameric quadruplex structure, supporting the idea that charge neutralization is a key component of perylene compounds that stabilize tetrameric quadruplexes.

Amino acid motifs in natural products: Synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine

(2S,3S)-3-Hydroxyleucine can be found in an increasing number of bioactive natural products. Within the context of our work regarding the total synthesis of muraymycin nucleoside antibiotics, we have developed a synthetic approach towards (2S,3S)-3- hydroxyleucine building blocks. Application of different protecting group patterns led to building blocks suitable for C- or N-terminal derivatization as well as for solid-phase peptide synthesis. With respect to according motifs occurring in natural products, we have converted these building blocks into 3-O-acylated structures. Utilizing an esterification and cross-metathesis protocol, (2S,3S)-3-hydroxyleucine derivatives were synthesized, thus opening up an excellent approach for the synthesis of bioactive natural products and derivatives thereof for structure activity relationship (SAR) studies.

Synthesis of donor-σ-perylenebisimide-acceptor molecules having PEG swallowtails and sulfur anchors

Donor-σ-Acceptor (D-σ-A) molecules, arrayed in a monolayer between electrodes, can serve as molecular rectifiers. Using perylene-3,4,9,10-tetracarboxylic bisimide (PBI) as the acceptor allows the attachment of the donor group to one imide nitrogen and a solubilizing swallowtail, normally a long (e.g., C19) alkane connected at midchain, on the other. Such an alkyl tail facilitates the formation of Langmuir-Blodgett (LB) monolayers. We have employed several modified swallowtails to make new D-σ-A molecules: poly(ethylene glycol) (PEG) swallowtails with 6 ether oxygens or with 4 ether oxygens to promote hydrophilicity in orienting LB monolayers, and alkyl swallowtails ending with sulfur anchors (thioacetate, thiol, or methyl disulfide) to stabilize attachment of the D-σ-A molecules to gold electrodes. The preparation and characterization of D-σ-A molecules containing combinations of these swallowtails with pyrene, ferrocene, and tetramethylphenylenediamine donor groups is described.