8050-07-5

Basic information

• Product Name: OLIBANUM GUM
• Synonyms: OLIBANUM GUM;FRANKINCENSE;GUM INCENSE;BOSWELLIA CARTERII OIL;OLBANUMGUM;OLIBANUMOILRESINOID;Boswellia carterii resin;Einecs 232-474-1
• CAS NO: 8050-07-5
• Molecular Formula: C₃₂H₄₈O₅
• Molecular Weight: 175.18242
• EINECS: 232-474-1
• Mol File: 8050-07-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 0.862-0.889
• CAS DataBase Reference: OLIBANUM GUM(CAS DataBase Reference)
• NIST Chemistry Reference: OLIBANUM GUM(8050-07-5)
• EPA Substance Registry System: OLIBANUM GUM(8050-07-5)

Safety Data

• Hazardous Substances Data: 8050-07-5(Hazardous Substances Data)

Usage

Description

Olibanum gum is yellowish to yellow-green transparent beaded solid. Soluble in ethanol, chloroform and ether; insoluble in turpentine; insoluble in water. Used in the system of varnish, chewing gum flavor, medicine, etc.

Upstream product

• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 5968-70-7 3-O-acetyl-β-boswellic acid 
• 631-69-6 beta-boswellic acid 

Downstream Products

• 5968-70-7 3-O-acetyl-β-boswellic acid 

Relevant articles and documents

Synthesis of new boswellic acid derivatives as potential antiproliferative agents

In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-acetyl-11-keto-β-boswellic acid (AKBA, 1) 11-keto-β-boswellic acid (KBA, 2) and several new bis-AKBA and KBA homodimers and AKBA-KBA heterodimers. The effects of these compounds on the proliferation of different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma), and A375 (malignant melanoma), have been evaluated. Thus, KBA homodimer 21 effectively inhibited the growth of FaDu, A2780, HT29, and A375 cells with EC50 values below 9 μM. In addition, compounds 7, 8, 11, 12, 15, 16, and 17 also exhibited cytotoxic effects for A2780, HT29, and A375 cancer cells. In particular, the pyrazine analog 8 was highly cytotoxic for A375 cancer cells with an EC50 value of 2.1 μM.

Oxidative and reductive transformations of 11-keto-β-boswellic acid

Extraction of frankincense - a fragrant resin obtained from plants of the genus Boswellia - followed by an oxidation furnished high yields of (3β) 3-O-acetyl-11-keto-β-boswellic acid (β-AKBA), a valuable starting material for accessing boswellic acid derivatives. Boswellic acids are fascinating triterpenoic acids that exhibit different biological activities. However, their biological potential, as well as that of their derivatives, remained unexploited due to their limited availability. In this study we were able to prepare derivatives of 11-keto-β-boswellic acid in good to excellent yields by oxidative and reductive transformations mainly in rings A and C of the triterpenoid skeleton. Among other transformations, a highly cytotoxic endoperoxide was obtained in excellent yields.

Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs

Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.