80518-48-5

Basic information

• Product Name: 6-fluoro-1,2,3,4-tetrahydro-2-methylquinolinium chloride
• Synonyms: 6-fluoro-1,2,3,4-tetrahydro-2-methylquinolinium chloride;Einecs 279-488-4
• CAS NO: 80518-48-5
• Molecular Formula: C₁₀H₁₂FN*ClH
• Molecular Weight: 201.6683232
• EINECS: 279-488-4
• Mol File: 80518-48-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 290.8°C at 760 mmHg
• Flash Point: 129.7°C
• Appearance: /
• Vapor Pressure: 0.00154mmHg at 25°C
• CAS DataBase Reference: 6-fluoro-1,2,3,4-tetrahydro-2-methylquinolinium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-1,2,3,4-tetrahydro-2-methylquinolinium chloride(80518-48-5)
• EPA Substance Registry System: 6-fluoro-1,2,3,4-tetrahydro-2-methylquinolinium chloride(80518-48-5)

Safety Data

• Hazardous Substances Data: 80518-48-5(Hazardous Substances Data)

Usage

Chemical Family

Quinolinium chloride

Structure

Contains a 6-fluoro substituted tetrahydroquinoline ring system

Synthesis

Synthetic organic compound

Applications

Pharmaceutical Research: Potential for drug development
Chemical Research: Building block in organic synthesis
Material Science: Possible applications
Biological Studies: Potential as a fluorescent probe

Unique Properties

Yet to be specified based on available information.

InChI:InChI=1/C10H12FN.ClH/c1-7-2-3-8-6-9(11)4-5-10(8)12-7;/h4-7,12H,2-3H2,1H3;1H

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid

An improved process for preparing the antimicrobial compound flumequine is disclosed. The first step of the process comprises reacting 4-fluoroaniline with crotonaldehyde under acidic conditions at a temperature between 50° and 60° C. In the second step, the product of the first step is slowly added to a refluxing solvent which forms a binary azeotrope with water and has a boiling point between 90° and 120° C. to provide a mixture of 6-fluoroquinaldine and 6-fluorotetrahydroquinaldine. This mixture is then treated with base in the presence of weak acid followed by reducing to provide 6-fluorotetrahydroquinaldine. This compound is then treated according to known procedures to form flumequine.

Intermediates for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid

Intermediates in a process for preparing the antimicrobial compound flumequine are disclosed. The intermediates have the following formula STR1 wherein R is hydrogen or alkyl having 1-3 carbon atoms and acid addition salts thereof.