805236-59-3

Upstream product

• 104218-44-2 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine 
• 10387-40-3 potassium thioacetate 

Downstream Products

• 164231-21-4 1-((2R,4S,5R)-4-Mercapto-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 805236-73-1 Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 805236-71-9 Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 805236-60-6 3'-(S)-(propargylthio)-5'-O-trityl-3'-deoxythymidine 
• 805236-64-0 3'-(S)-(allenic sulfonyl)-5'-benzoyl-3'-deoxythymidine 
• 805236-62-8 Benzoic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-prop-2-ynylsulfanyl-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxyguanosine (AzddGuo), 3'-fluoro-ddGuo (FddGuo), and 3'-fluoro-2,6-diaminopurine 2',3'-dideoxynucleoside (FddDAPR) were the most selective inhibitors of HIV replication.

Synthesis and reactions of allenic sulfone-modified thymidine: The first allenic sulfone to alkylate deoxyadenosine

3′-(S)-(allenic sulfonyl)-5?-benzoyl-3?-deoxythymidine has been synthesized from 1-(5-O-trityl-3-O-mesyl-2-deoxy-β-D- threopentofuranosyl) thymine via 3′-(S)-(propargylthio)-5′-trityl- 3′-deoxythymidine in six steps. 3′-(S)-(allenic sulfonyl)-3′- deoxythymidine reacts very efficiently with a wide array of nucleophiles. This is also the first report on the alkylation of adenine moiety by some allenic sulfone modified compounds.