805236-64-0

Upstream product

• 805236-60-6 3'-(S)-(propargylthio)-5'-O-trityl-3'-deoxythymidine 
• 164231-21-4 1-((2R,4S,5R)-4-Mercapto-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 805236-61-7 3'-deoxy-3'-(S)-(propargylthio)thymidine 
• 805236-59-3 5'-O-trityl-3'-(acetylthio)-2',3'-dideoxythymidine 
• 104218-44-2 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine 
• 805236-62-8 Benzoic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-prop-2-ynylsulfanyl-tetrahydro-furan-2-ylmethyl ester 

Downstream Products

• 805236-71-9 Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 805236-73-1 Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and reactions of allenic sulfone-modified thymidine: The first allenic sulfone to alkylate deoxyadenosine

3′-(S)-(allenic sulfonyl)-5?-benzoyl-3?-deoxythymidine has been synthesized from 1-(5-O-trityl-3-O-mesyl-2-deoxy-β-D- threopentofuranosyl) thymine via 3′-(S)-(propargylthio)-5′-trityl- 3′-deoxythymidine in six steps. 3′-(S)-(allenic sulfonyl)-3′- deoxythymidine reacts very efficiently with a wide array of nucleophiles. This is also the first report on the alkylation of adenine moiety by some allenic sulfone modified compounds.