805245-44-7Relevant articles and documents
Structure-Activity Relationships of Neplanocin A Analogues as S -Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities
Chandra, Girish,Moon, Yang Won,Lee, Yoonji,Jang, Ji Yong,Song, Jayoung,Nayak, Akshata,Oh, Kawon,Mulamoottil, Varughese A.,Sahu, Pramod K.,Kim, Gyudong,Chang, Tong-Shin,Noh, Minsoo,Lee, Sang Kook,Choi, Sun,Jeong, Lak Shin
, p. 5108 - 5120 (2015/07/02)
On the basis of the potent inhibitory activity of neplanocin A (1) against S-adenosylhomocysteine (AdoHcy) hydrolase, we analyzed the comprehensive structure-activity relationships by modifying the adenine and carbasugar moiety of 1 to find the pharmacoph
Synthesis of 5′-substituted fluoro-neplanocin A analogues: Importance of a hydrogen bonding donor at 5′-position for the inhibitory activity of S-adenosylhomocysteine hydrolase
Moon, Hyung Ryong,Lee, Hyun Joo,Kim, Kyung Ran,Lee, Kang Man,Lee, Sang Kook,Kim, Hea Ok,Chun, Moon Woo,Jeong, Lak Shin
, p. 5641 - 5644 (2007/10/03)
Four 5′-substituted fluoro-neplanocin A analogues 1a-d were designed and synthesized to study structure-activity relationship against SAH. The inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a