805245-45-8Relevant academic research and scientific papers
Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and – pyrimidines
Yoon, Ji-seong,Jarhad, Dnyandev B.,Kim, Gyudong,Nayak, Akshata,Zhao, Long Xuan,Yu, Jinha,Kim, Hong-Rae,Lee, Ji Yun,Mulamoottil, Varughese A.,Chandra, Girish,Byun, Woong Sub,Lee, Sang Kook,Kim, Yong-Chul,Jeong, Lak Shin
, p. 406 - 417 (2018/06/26)
Based on the potent anticancer activity of 6′-fluorocyclopentenyl-cytosine 2b in phase IIa clinical trials for the treatment of gemcitabine-resistant pancreatic cancer, we carried out a systematic structure-activity relationship study of 6′-fluorocyclopen
Structure-activity relationship of 5′-substituted fluoro-neplanocin A analogues as potent inhibitors of S-adenosylhomocysteine hydrolase
Moon, Hyung Ryong,Lee, Kang Man,Lee, Hyun Joo,Lee, Sang Kook,Park, Seung Bin,Chun, Moon Woo,Jeong, Lak Shin
, p. 707 - 708 (2007/10/03)
Four 5′-substituted fluoro-neplanocin A analogues 1a-d were designed and synthesized, and the inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a hydrogen bonding donor is essential for inhibito
Synthesis of 5′-substituted fluoro-neplanocin A analogues: Importance of a hydrogen bonding donor at 5′-position for the inhibitory activity of S-adenosylhomocysteine hydrolase
Moon, Hyung Ryong,Lee, Hyun Joo,Kim, Kyung Ran,Lee, Kang Man,Lee, Sang Kook,Kim, Hea Ok,Chun, Moon Woo,Jeong, Lak Shin
, p. 5641 - 5644 (2007/10/03)
Four 5′-substituted fluoro-neplanocin A analogues 1a-d were designed and synthesized to study structure-activity relationship against SAH. The inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a
