805247-01-2

Upstream product

• 805247-00-1 Acetic acid (Z)-(1S,2S)-1-(2-benzyloxy-ethyl)-5-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxymethyl)-pent-3-enyl ester 
• 805246-99-5 (3S,4S)-1-Benzyloxy-7-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-4-(4-methoxy-benzyloxymethyl)-hept-5-yn-3-ol 
• 805247-15-8 (Z)-(3S,4S)-1-Benzyloxy-7-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-4-(4-methoxy-benzyloxymethyl)-hept-5-en-3-ol 
• 805246-98-4 (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(4-methoxy-benzyloxymethyl)-oxirane 
• 824-94-2 p-methoxybenzyl chloride 
• 126107-76-4 (2R,3S)-3-[2-(benzyloxy)ethyl]oxiran-2-methanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 253128-09-5 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl) ethyl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate 
• 253127-98-9 C₅₂H₉₀O₁₀Si₂ 
• 253128-08-4 C₅₀H₈₆O₈SSi₂ 
• 253128-10-8 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol 
• 252904-99-7 2-[(2S,3S,4R,5R)-5-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-ethanol 
• 252905-00-3 [(2S,3S,4R,5R)-5-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-acetaldehyde 
• 805247-02-3 (S)-4-[(2R,3R,4S,5S)-5-(2-Benzyloxy-ethyl)-3-methoxy-4-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-ylmethyl]-2,2-diethyl-[1,3]dioxolane 

Relevant academic research and scientific papers

Macrocyclic ketone analogues of halichondrin B

Synthesis and SAR studies of structurally simplified analogues of marine natural product halichondrin B resulted in the discovery of E7389, a new potential antitumor agent currently undergoing Phase I clinical trials. Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.