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Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5,6-dihydro-4H-benzothiazol-7-one hydrobromide is used as an intermediate in the preparation of dihydrobenzofuranacetic acid derivatives for their potential antidiabetic properties. 2-AMino-5,6-dihydro-4H-benzothiazol -7-one hydrobroMide plays a crucial role in the development of new drugs to manage and treat diabetes, offering a promising avenue for improving the lives of those affected by the condition.

Upstream product

• 60060-44-8 2-bromocyclohexane-1,3-dienone 
• 17356-08-0 thiourea 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 1244656-98-1 (6S,7R)-N6-propyl-N7-((S)-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol-2-yl)-4,5,6,7-tetrahydrobenzothiazole-2,6,7-triamine 
• 1001648-73-2 2-amino-6-bromo-5,6-dihydrobenzothiazol-7(4H)-one 

Relevant academic research and scientific papers

Synthesis of Impurities of Pramipexole Dihydrochloride

Three impurities of pramipexole dihydrochloride were synthesized, and the possible generation mechanisms and the preparation methods of some impurities were reviewed. The desired configuration at C7 of 3 was built by a Mitsunobu reaction.

Azole derivatives as histamine H3 receptor antagonists, Part I: Thiazol-2-yl ethers

Most human histamine H3 receptor (hH3R) antagonists follow a general structural blueprint, containing a basic moiety linked by a spacer to a substituted core element. In this investigation the acceptance of thiazol-2-yl ether moieties in the core region is proved with some ether derivatives showing hH3R binding affinities in the nanomolar concentration range. A diversity of structural motifs is used as substituents to enhance the in vitro hH3R binding affinity.