80533-34-2Relevant academic research and scientific papers
Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation
Ogasawara, Sari,Kiyota, Yuhei,Chuman, Yoshiro,Kowata, Ayano,Yoshimura, Fumihiko,Tanino, Keiji,Kamada, Rui,Sakaguchi, Kazuyasu
, p. 6246 - 6249 (2015)
Protein phosphatase magnesium-dependent 1δ (PPM1D, Wip1) is a p53 inducible serine/threonine phosphatase. PPM1D is a promising target protein in cancer therapy since overexpression, missense mutations, truncating mutations, and gene amplification of PPM1D
Intramolecular C-H insertion reactions of (η5-Cyclopentadienyl)dicarbonyliron carbene complexes: Scope of the reactions and application to the synthesis of (±)-sterpurene and (±)-pentalenene
Ishii,Zhao,Mehta,Knors,Helquist
, p. 3449 - 3458 (2007/10/03)
(η5-Cyclopentadienyl)dicarbonyliron carbene complexes, [(η5C5H5) (CO)2Fe=CHR]+BF4-, are generated as reactive intermediates from thioether derivatives, (η5-C5H5)(CO)2FeCH(R)SPh, by S-alkylation with trimethyloxonium tetrafluoroborate and loss of thioanisole. The carbene complexes undergo intramolecular C-H insertion into appropriately situated side chains to form cyclopentane derivatives. The reaction has been developed into a general procedure employing cycloalkanones as scaffolds bearing the iron carbene moieties and the side chains at C(2) and C(3), respectively. The products of the intramolecular insertion reactions are substituted bicyclo[n.3.0]alkanones. The scope and limitations of the reaction are described. The reaction is applied to a total synthesis of sterpurene and to a formal synthesis of pentalenene. Overall, this approach to cyclopentane annulation complements the related metal-catalyzed insertion reactions of diazocarbonyl compounds, which are also believed to occur via metal carbene complexes.
α Vinylation of Ketones. A General Method Using a (Phenylseleno)acetaldehyde
Clive, Derrick L.J.,Russell, Charles G.,Suri, Suresh Chander
, p. 1632 - 1641 (2007/10/02)
(Phenylseleno)acetaldehyde can be used as a synthetic equivalent of the vinyl carbonium ion, CH2=CH2+.A number of ketone enolates, usually as zinc salts, were condensed with (phenylseleno)acetaldehyde to give β-hydroxy selenides (average yield
