8057-25-8

Basic information

• Product Name: Brn 2816456
• Synonyms: Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L-;Brn 2816456
• CAS NO: 8057-25-8
• Molecular Weight: 0
• Mol File: 8057-25-8.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Brn 2816456(CAS DataBase Reference)
• NIST Chemistry Reference: Brn 2816456(8057-25-8)
• EPA Substance Registry System: Brn 2816456(8057-25-8)

Safety Data

• Hazardous Substances Data: 8057-25-8(Hazardous Substances Data)

Upstream product

• 297734-00-0 4-(bis-(2-hydroxyethyl)amino)-L-phenylalanine 
• 75-21-8 oxirane 
• 1195524-16-3 4-amino-N,N-phthaloyl-D-phenylalanin-ethyl ester 
• 380449-51-4 ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate 
• 3223-07-2 melphalan hydrochloride 
• 189744-28-3 N-(tert-butyloxycarbonyl)-4-(bis(2-chloroethyl)amino)-L-phenylalanine ethyl ester 
• 189744-27-2 N-boc-L-3-(4-bis(hydroxyethyl)aminophenyl)alanine ethyl ester 
• 67630-01-7 (S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester 
• 1217651-06-3 N-(t-butyloxycarbonyl)-4-[bis(2-hydroxyethyl)amino]-L-phenylalanine methyl ester 
• 62978-52-3 melphalan methyl ester hydrochloride salt 
• 6335-21-3 diethyl 2-acetamido-2-(4-aminobenzyl)malonate 
• 6265-87-8 2-acetylamino-2-(4-nitrobenzyl)malonic acid diethyl ester 
• 83772-59-2 4-<4-benzylidene>-4'-N,N-dimethylaminoaniline 
• 90897-97-5 4-<4-benzylidene>2-phenyl-2-oxazolin-5-one 

Downstream Products

• 23583-14-4 NPS-Sarcolysin 
• 72143-20-5 C₁₃H₂₀N₂O₄ 

Relevant articles and documents

Aminopeptidase expression in multiple myeloma associates with disease progression and sensitivity to melflufen

Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells. Aminopeptidases contribute to proteolysis by catalyzing the hydrolysis of amino acids from proteins or peptides and function downstream of the ubiquitin–proteasome pathway. Notably, aminopeptidases can be utilized in the delivery of antibody and peptide-conjugated drugs, such as melflufen, currently in clinical trials. We analyzed the expression of 39 aminopeptidase genes in MM samples from 122 patients treated at Finnish cancer centers and 892 patients from the CoMMpass database. Based on ranked abundance, LAP3, ERAP2, METAP2, TTP2, and DPP7 were highly expressed in MM. ERAP2, XPNPEP1, DPP3, RNPEP, and CTSV were differentially expressed between relapsed/refractory and newly diagnosed MM samples (p a substrate for aminopeptidases LAP3, LTA4H, RNPEP, and ANPEP. The sensitivity of MM cell lines to melflufen was reduced by aminopeptidase inhibitors. These results indicate critical roles of aminopeptidases in disease progression and the activity of melflufen in MM.

An Improved Process for the Synthesis of Melphalan and the Hydrochloride Salt

The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I).

PROCESS FOR THE PREPARATION OF MELPHALAN HYDROCHLORIDE

The present invention provides a simple and efficient method for synthesis of 4-[bis (2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride of desired purity.