6265-87-8

Basic information

• Product Name: diethyl (acetylamino)(4-nitrobenzyl)propanedioate
• CAS NO: 6265-87-8
• Molecular Formula: C₁₆H₂₀N₂O₇
• Molecular Weight: 352.3392
• Mol File: 6265-87-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 526.9°C at 760 mmHg
• Flash Point: 272.5°C
• Density: 1.262g/cm³
• Vapor Pressure: 3.43E-11mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: diethyl (acetylamino)(4-nitrobenzyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (acetylamino)(4-nitrobenzyl)propanedioate(6265-87-8)
• EPA Substance Registry System: diethyl (acetylamino)(4-nitrobenzyl)propanedioate(6265-87-8)

Safety Data

• Hazardous Substances Data: 6265-87-8(Hazardous Substances Data)

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 3235-26-5 2-(N-acetylamino)-2-benzylpropanedioic diethyl ester 

Downstream Products

• 127090-51-1 2-acetylamino-3-(4-nitro-phenyl)-propionic acid methyl ester 
• 127641-82-1 4-nitro-D-phenylalanine ethyl ester; hydrochloride 
• 13057-62-0 acetylamino-{4-[bis-(2-hydroxy-ethyl)-amino]-benzyl}-malonic acid diethyl ester 
• 36097-40-2 N-acetyl-4-nitro-D-phenylalanine ethyl ester 
• 89615-73-6 N-acetyl-4-nitro-D-phenylalanine 
• 56613-61-7 (R)-4-nitro-phenylalanine 
• 29553-99-9 N-acetyl-4-acetylamino-phenylalanine 
• 36097-40-2 (S)-ethyl 2-acetamido-3-(4-nitrophenyl)propanoate 
• 59515-83-2 4-amino-3,5-diiodo-phenylalanine 
• 2922-41-0 (p-aminophenyl)alanine 
• 17363-92-7 N-acetyl-4-nitro-L-phenylalanine 
• 531-76-0 melphalan 
• 163251-51-2 2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride 
• 856571-39-6 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-nitrophenyl)propionic acid ethyl ester 

Relevant articles and documents

S-Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low Potentials

Electrochemical sensors are essential for point-of-care testing (POCT) and wearable sensing devices. Establishing an efficient electron transfer route between redox enzymes and electrodes is key for converting enzyme-catalyzed reactions into electrochemical signals, and for the development of robust, sensitive, and selective biosensors. We demonstrate that the site-specific incorporation of a novel synthetic amino acid (2-amino-3-(4-mercaptophenyl)propanoic acid) into redox enzymes, followed by an S-click reaction to wire the enzyme to the electrode, facilitates electron transfer. The fabricated biosensor demonstrated real-time and selective monitoring of tryptophan (Trp) in blood and sweat samples, with a linear range of 0.02–0.8 mm. Further developments along this route may result in dramatic expansion of portable electrochemical sensors for diverse health-determination molecules.

Anthranilic acid based CCK1 receptor antagonists: Preliminary investigation on their second "touch point"

In this phase of structure-affinity relationship study of VL-0395, a new anthranilic acid based CCK1 selective antagonist, we propose a series of unnatural aminoacidic derivatives. The result of this work is the identification of a new CCK ligand, which possesses an affinity (IC50 = 35 nm) one order of magnitude greater than the lead and, as a general rule, it points out how the hypothesized receptorial pocket which accommodates the Phe residue allows much more structural modification than that interacting with the N-terminal group. Hence, the modification of the C-terminal pharmacophoric group of our lead VL-0395 can not only enhance the affinity of anthranilic acid derivatives but can modulate the selectivity for one CCK receptor subtype or afford mixed antagonists.