80591-41-9 Usage
Uses
Used in Pharmaceutical Synthesis:
3-ISOCYANATO-1-(TRIFLUOROACETYL)PIPERIDINE is utilized as a key intermediate in the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, making it a valuable component in medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 3-ISOCYANATO-1-(TRIFLUOROACETYL)PIPERIDINE serves as a building block for the creation of various agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used as a Reagent in Organic Synthesis:
3-ISOCYANATO-1-(TRIFLUOROACETYL)PIPERIDINE is employed as a reagent in organic synthesis, where its reactive nature facilitates various chemical reactions. This makes it a useful tool for chemists working on the development of new organic compounds and materials.
Used in the Production of Chemical Derivatives:
As a building block, 3-ISOCYANATO-1-(TRIFLUOROACETYL)PIPERIDINE is also used in the production of a range of chemical derivatives. Its versatility in chemical reactions allows for the creation of diverse products across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 80591-41-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,5,9 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 80591-41:
(7*8)+(6*0)+(5*5)+(4*9)+(3*1)+(2*4)+(1*1)=129
129 % 10 = 9
So 80591-41-9 is a valid CAS Registry Number.
80591-41-9Relevant academic research and scientific papers
Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition
Meneghetti, Fiorella,Villa, Stefania,Masciocchi, Daniela,Barlocco, Daniela,Toma, Lucio,Han, Dong-Cho,Kwon, Byoung-Mog,Ogo, Naohisa,Asai, Akira,Legnani, Laura,Gelain, Arianna
supporting information, p. 4907 - 4912 (2015/08/03)
Three new ureido-pyridazinone derivatives, which are structurally related to the known STAT3 inhibitor AVS-0288, were designed by taking into account the structure-activity relationships determined for several ureido-oxadiazole derivatives previously studied by our group. Their synthesis was first attempted through suitable 5-aminopyridazinone intermediates (6a and 6b), which molecular structures were confirmed by means of X-ray diffraction data on 6a. Amine functionalization was unsuccessful, therefore, an alternative method was devised. Dual-luciferase and AlphaScreen-based assays were used to test their activity. The obtained data were rationalized on the basis of a modeling study, which focused our attention on the geometrical preferences of the ureido moiety. Computational results seem to indicate that both the 1,2,5-oxadiazole ring and the extended ZZ arrangement are essential and probably act in a synergistic way to confer significant activity against STAT3.
