805994-92-7Relevant academic research and scientific papers
Uncovering an allosteric mode of action for a selective inhibitor of human bloom syndrome protein
Chen, Xiangrong,Ali, Yusuf I.,Fisher, Charlotte EL,Arribas-Bosacoma, Raquel,Rajasekaran, Mohan B.,Williams, Gareth,Walker, Sarah,Booth, Jessica R.,Hudson, Jessica JR,Mark Roe,Pearl, Laurence H.,Ward, Simon E.,Pearl, Frances MG,Oliver, Antony W.
, (2021/04/02)
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage r
Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions
Tang, Xiaodong,Yang, Jidan,Zhu, Zhongzhi,Zheng, Meifang,Wu, Wanqing,Jiang, Huanfeng
, p. 11461 - 11466 (2016/11/28)
A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N-O/C-S bond cleavages, activation of vinyl sp2 C-H bond, and C-S/C-N bond formations which are under redox-neutral conditions as well as operational simplicity.
PIPERAZINE AND PIPERIDINE BIARYL DERIVATIVES
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Page/Page column 76, (2010/11/28)
This invention relates to piperazine and piperidine biaryl compounds of Formula (I) or a pharmaceutically acceptable prodrug, salt, polymorph, solvate, enantiomer, diastereomer, racemate, mixture of stereoisomers thereof, or derivative thereof; and to processes for preparing the compounds or pharmaceutical compositions containing the same. The compounds and pharmaceutical compositions of the present invention are provided for use in the treatment of HIV infection and/or AIDS.
Benzamide nitriles
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Page 35-36, (2010/02/09)
Compounds of the formula (I) wherein m, n, A, R1, R2, R3, R4, R5 and R6 are as described herein, together with methods for making the compounds and using the compounds for treatment of diseases or conditions mediated by Cathepsin K.
