80613-04-3Relevant articles and documents
NEW 5-AMINOLEVULINIC ACID PRODRUGS FOR USE IN PHOTODYNAMIC THERAPY AND PHOTODYNAMIC DIAGNOSIS
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Page/Page column 21; 23, (2010/04/06)
There is provided a compound of Formula (I) or (II) and salts thereof wherein R1 is an imine or an alkylated imine, said imine or alkylated imine comprising a linear or branched alkyl group of length C1 to C5; R2 are each independently (a) an unsubstituted or substituted linear or branched alkyl group of chain length C1-7; (b) an aryl substituted alkyl group, wherein said aryl group is substituted, (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group,; or (d) an H atom; wherein said substituents in (a) and (b) are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo and fluoro groups. R3 and R4 are linear or branched alkyl groups of length C1 to C6 constituting a ketal or a cyclic ketal. The compounds claimed may be used for the manufacture of a medicament.
GABA uptake inhibitors. Syntheses and structure-activity studies on GABA analogues containing diarylbutenyl and diarylmethoxyalkyl N-substituents
Falch,Krogsgaard-Larsen
, p. 69 - 77 (2007/10/02)
A number of analogues of GABA or β-alanine containing 4,4-diphenyl-3-butenyl (DPB), benzhydryl ethyl ether (BEE), or benzhydryl propyl ether N-substituents have been synthesized and tested as inhibitors of synaptosomal GABA uptake. Whereas the N-DPB and N
Syntheses of Some Aminopiperidinecarboxylic Acids Related to Nipecotic Acid
Jacobsen, Poul,Schaumburg, Kjeld,Larsen, Jens-Joergen,Krogsgaard-Larsen, Povl
, p. 289 - 294 (2011/02/21)
This paper describes the syntheses of (3RS,5SR)-5-hydroxypiperidine-3-carboxylic acid (8), (3RS,5SR)-5-aminoperidine-3-carboxylic acid (9), (RS)-3-hydroxypiperidine-3-carboxylic acid (13), (RS)-α-amino-3-pyridineacetic acid (18), and α-amino-3-piperidineacetic acid (19), compound 19 probably being a mixture of diastereomeric racemates.The compounds 8 and 9 were prepared from 5-aminonicotinic acid by catalytic hydrogenation.The relative stereochemistry of 9 was established by 270 MHz 1H NMR spectroscopy.The α-hydroxy acid 13 was prepared via cyanhydrin reaction of the 3-piperidone derivative 11.The α-amino acids 18 and 19 were prepared from 3-pyridineacetic acid by nitrosation and subsequent catalytic hydrogenation.