61995-18-4

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperidine carboxylic acid-3-oxo-Methyl ester is used as a key intermediate in the synthesis of various drugs. Its unique structure allows it to be a versatile building block in the development of new pharmaceutical compounds.
Used in Agrochemical Industry:
1-Piperidine carboxylic acid-3-oxo-Methyl ester is also used in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products.
Used in Material Science:
1-Piperidine carboxylic acid-3-oxo-Methyl ester has potential applications in the development of new materials, where its chemical properties can be utilized to create innovative and improved materials for various industries.
Used in Organic Synthesis:
1-Piperidine carboxylic acid-3-oxo-Methyl ester serves as a valuable building block in organic synthesis, enabling the creation of a wide range of organic compounds for research and industrial applications.
It is important to handle 1-Piperidine carboxylic acid-3-oxo-Methyl ester with care, as it may be hazardous if not used properly.

Upstream product

• 56475-87-7 3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 80613-04-3 3-hydroxypiperidine-1-carboxylic acid methyl ester 
• 50606-58-1 N-benzyl-3-piperidinone hydrochloride 
• 79-22-1 methyl chloroformate 
• 40114-49-6 1-benzyl-3-piperidone 

Downstream Products

• 5451-09-2 5-aminolevulinic acid hydrochloride 
• 1000893-93-5 C₃₆H₄₀F₆N₄O₅ 
• 1000894-33-6 C₁₉H₂₂F₃NO₅ 
• 1132910-38-3 methyl 3-(2-(tert-butoxycarbonylamino)phenyl)-3-hydroxypiperidine-1-carboxylate 
• 866823-00-9 2-(2-bromo-5-methoxybenzyl)-3-hydroxy-3,5-bis(3-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 866822-97-1 2-(2-bromo-5-methoxybenzyl)-3-hydroxy-3-(3-methoxyphenyl)-piperidine-1-carboxylic acid methyl ester 
• 866822-99-3 2-(2-bromo-5-methoxybenzyl)-5-(3-methoxyphenyl)-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 866822-95-9 2-(2-bromo-5-methoxybenzyl)-3-hydroxy-3-(3-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 866822-90-4 3-hydroxy-2-(3-methoxybenzyl)-3-(3-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 866822-93-7 2-(2-bromo-5-methoxybenzyl)-3-oxopiperidine-1-carboxylic acid methyl ester 
• 866822-94-8 2-(2-bromo-5-methoxybenzyl)-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 866822-89-1 2-(3-methoxybenzyl)-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 80613-04-3 3-hydroxypiperidine-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Pivotal role of an aliphatic side chain in the development of an HDM2 inhibitor

Introduction of an aliphatic side chain to a key position of a novel piperidine-based HDM2 inhibitor scaffold resulted in significant potency gains, enabling further series progression.

NEW 5-AMINOLEVULINIC ACID PRODRUGS FOR USE IN PHOTODYNAMIC THERAPY AND PHOTODYNAMIC DIAGNOSIS

There is provided a compound of Formula (I) or (II) and salts thereof wherein R1 is an imine or an alkylated imine, said imine or alkylated imine comprising a linear or branched alkyl group of length C1 to C5; R2 are each independently (a) an unsubstituted or substituted linear or branched alkyl group of chain length C1-7; (b) an aryl substituted alkyl group, wherein said aryl group is substituted, (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group,; or (d) an H atom; wherein said substituents in (a) and (b) are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo and fluoro groups. R3 and R4 are linear or branched alkyl groups of length C1 to C6 constituting a ketal or a cyclic ketal. The compounds claimed may be used for the manufacture of a medicament.

Substituted Piperidines that Increase P53 Activity and the Uses Thereof

In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

Facile synthesis of the indeno-tetrahydropyridine core of haouamine A

(Chemical Equation Presented) The tricyclic indeno-tetrahydropyridine core of haouamine A, containing five of the seven rings of the natural product, was constructed by a simple, concise route that features an acid-catalyzed Friedel-Crafts ring closure.

A convenient method for introducing oxo group into the β-position of cyclic amines and its application to synthesis of δ-aminolevulinic acid

Oxo group could be introduced into the β-position of N-methoxycarbonylated cyclic amines by utilizing electrochemical oxidation and/or m-chloroperbenzoic acid oxidation, and this method was applied to the preparation of δ-aminolevulinic acid, an intermediate of chlorophyll biosynthesis.