80615-41-4

Upstream product

• 25458-46-2 4-methoxyphenyl methoxymethyl ether 
• 814-49-3 diethyl chlorophosphate 
• 51496-03-8 diisopropyl phenyl phosphate 
• 5076-68-6 diethyl 4-methoxyphenyl phosphate 
• 150-76-5 4-methoxy-phenol 
• 762-04-9 phosphonic acid diethyl ester 

Downstream Products

• 1335044-32-0 C₁₅H₁₆F₉O₇PS 
• 91633-13-5 (2-Hydroxy-5-methoxy-1,3-phenylene)bis(phosphonic acid) 
• 91633-10-2 Tetraethyl (2-hydroxy-5-methoxy-1,3-phenylene)bis(phosphonate) 
• 91633-05-5 (2-Hydroxy-5-methoxyphenyl)phosphonic acid 
• 129529-21-1 2-(Diethyl-phosphinoyl)-4-methoxy-phenol 
• 91633-08-8 Diethyl 2-(diethoxyphosphinyl)-4-methoxyphenyl phosphate 

Relevant academic research and scientific papers

Synthesis and Complexation Properties of 2-Hydroxy-5-methoxyphenylphosphonic Acid (H3L1). Crystal Structure of the [Cu(H2L1)2(Н2О)2] Complex

Abstract: 2-Hydroxy-5-methoxyphenylphosphonic acid (H3L1) and the complex [Cu(H2L1)2(H2O)2] were synthesized and characterized by IR spectroscopy, thermogravimetry, and X-ray dif

Stereoselective synthesis of phosphoryl-substituted phenols

Copper-catalyzed C-X activation-phosphorylation of aryls bearing different groups has been achieved using P(O)-H compounds as efficient phosphorylation reagents without the assistance of any ligand. Optically active H-phosphinates can also act as good substrates in the reaction, giving the (Sp)-phosphoryl substituted phenolic compounds stereospecifically with retention of configuration at the phosphorus center. Furthermore, it is shown that the migration of phosphorus on O-aryl phosphonates from oxygen to carbon also proceeds stereospecifically to produce the corresponding optically active (Rp)-phosphoryl-substituted phenolic compounds with retention of configuration at phosphorus via treatment with lithium diisopropylamide (LDA). Plausible mechanisms have been proposed for these reactions.

Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase

Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in atherosclerosis and for the development of hypocholesterolemic agents, there are increasing interests in designing and synthesizing CEase inhibitors. In the present study, we prepared forty-five isocoumarin phosphorus analogues (i.e., phosphaisocoumarins) and investigated the inhibition of these compounds on the CEase. The results showed that some phosphaisocoumarins could act as potent inhibitors of CEase. The most potent inhibitors, compounds 9d, 10a and 12e give IC50 values of 4.8?μM, 2.3?μM and 1.9?μM, respectively. The inhibition mechanism and kinetic characterization studies indicate that they are reversible competitive inhibitors.

SYNTHESIS AND SUBSTITUENT EFFECT ON 31P NMR CHEMICAL SHIFT OF ORTHO-HYDROXYARYL DIALKYL PHOSPHINE OXIDES

In this paper, the synthetic methods for the preparation of o-hydroxyaryl dialkyl phosphine oxides (1) are introduced.The title compounds with low bulky substituent are synthesized successfully by the reactions of Grignard reagents with diethyl o-hydroxya

o-Hydroxyaryl Diphosphonic Acids

Treatment of dialkyl aryl phosphates with n-butyllithium or lithium diisopropylamide results in a rearrangement that involves the fission of an oxygen-phosphorus bond and formation of a C-P bond yielding dialkyl (2-hydroxyaryl)phosphonates.A dialkyl (2-hy

AN EFFICIENT SYNTHESIS OF 2-HYDROXYPHENYLPHOSPHONATES

The high yield conversion of phenols into diethyl 2-hydroxyphenylphosphonates via base catalyzed rearrangement of diethyl phenyl phosphates has been achieved.