80629-35-2 Usage
Uses
Used in Pharmaceutical Industry:
1-[(2S)-3-Bromo-2-methyl-1-oxopropyl]-L-proline is used as a key intermediate in the synthesis of Captopril (C175750), an orally active angiotensin-converting enzyme (ACE) inhibitor. 1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline plays a crucial role in the development of medications for the treatment of hypertension and certain types of congestive heart failure.
Check Digit Verification of cas no
The CAS Registry Mumber 80629-35-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,6,2 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 80629-35:
(7*8)+(6*0)+(5*6)+(4*2)+(3*9)+(2*3)+(1*5)=132
132 % 10 = 2
So 80629-35-2 is a valid CAS Registry Number.
80629-35-2Relevant academic research and scientific papers
Nam,Lee,Ryu
, p. 1843 - 1844 (1984)
An improved synthesis of captopril using methacrylic acid as the starting material is described. Treatment of methacrylic acid (I) with a hydrogen halide gave the 3-halogeno-2-methylpropanoic acids II and III, which were treated with thionyl chloride to yield the corresponding 3-halogeno-2-methylpropanoyl chlorides IV and V. Treatment of IV or V with L-proline yielded the N-(R,S-3-halogeno-2-methylpropanoyl)-L-prolines VI and VII, which were separated into optically pure R- and S-diastereoisomers using dicyclohexylamine. Treatment of halides of VI or VII with methanolic ammonium hydrosulfide gave captopril in 28% yield.
