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Z-Phe-ONp-Pic, also known as N-benzoyl-L-phenylalanyl-1-naphtyl ester, is a synthetic peptide compound consisting of a phenylalanine (Phe) residue, a hydroxamic acid (ONp) group, and a picolinic acid (Pic) moiety. Z-Phe-ONp-Pic is often used in the study of proteases, particularly cysteine proteases, as it serves as a substrate for these enzymes. The hydroxamic acid group mimics the transition state of the peptide bond cleavage, while the picolinic acid acts as a chromophore, allowing for the detection and quantification of protease activity through changes in absorbance upon cleavage. Z-Phe-ONp-Pic is a valuable tool in biochemical research, providing insights into the mechanisms and specificities of proteolytic enzymes.

80633-16-5

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80633-16-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80633-16-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,6,3 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 80633-16:
(7*8)+(6*0)+(5*6)+(4*3)+(3*3)+(2*1)+(1*6)=115
115 % 10 = 5
So 80633-16-5 is a valid CAS Registry Number.

80633-16-5Downstream Products

80633-16-5Relevant academic research and scientific papers

Protected Amino Acid Active Esters Incorporating the 4-Picolyl Basic Solubilizing Group

Stewart, Frederick H. C.

, p. 2013 - 2017 (2007/10/02)

The 4-picolyl ester of 4-hydroxy-3-nitrophenylacetic acid has been prepared from an active polyester intermediate, and used as the precursor of a series of protected amino acid active esters.These compounds were satifactory coupling components in peptide syntheses.Purification of the protected peptides by acid washing was facilitated by the presence of the basic 4-picolyl moiety.

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