80648-84-6

Upstream product

• 5341-58-2 3-hydroxy-2-naphthohydrazide 
• 90-02-8 salicylaldehyde 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 92-70-6 3-Hydroxy-2-naphthoic acid 

Relevant academic research and scientific papers

Toward the discovery of dual inhibitors for botulinum neurotoxin A: Concomitant targeting of endocytosis and light chain protease activity

Dyngo-4a has been found to be an endocytic inhibitor of BoNT/A neurotoxicity through dynamin inhibition. Herein, we demonstrate this molecule to have a previously unrecognized dual activity against BoNT/A, dynamin-protease inhibition. To establish the imp

ONO pincer type Pd(II) complexes: Synthesis, crystal structure and catalytic activity towards C-2 arylation of quinoline scaffolds

Four new palladium(II) complexes featuring ONO pincer type hydrazone ligands were synthesized and characterized by spectroscopic and single-crystal XRD analysis. These complexes showed excellent catalytic activity towards the Suzuki-Miyaura cross coupling reaction of 2-chloroquinoline derivatives with various aryl boronic acids. The main advantages over previous methodologies include low catalyst loading, less problematic reaction media (H2O-DMF (80:20%)) and a lower reaction temperature of 60 °C for optimal performance.

Structure-activity relationships in non-ligand binding pocket (Non-LBP) diarylhydrazide antiandrogens

We report the synthesis and a study of the structure-activity relationships of a new series of diarylhydrazides as potential selective non-ligand binding pocket androgen receptor antagonists. Their biological activity as antiandrogens in the context of the development of treatments for castration resistant prostate cancer was evaluated using in vitro time resolved fluorescence resonance energy transfer and fluorescence polarization on target assays. Additionally, a theoretical study combining docking and molecular dynamics methods was performed to provide insight into their mechanism of action as a basis for further lead optimization studies.

Synthesis, structural characterization and thermal properties of three copper(II) complexes based on aryl hydrazide ligands

The thiosemicarbazide and hydrazide Cu(II) complexes, [Cu3L 21(py)4Cl2] (1), [Cu(HL 2)py] (2) and [Cu(HL3)py] (3), (H2L1 = 1-picolinoylthiosemicarbazide, H

Homogeneous green catalysts for olefin oxidation by mono oxovanadium(V) complexes of hydrazone Schiff base ligands

Three mono oxovanadium(V) complexes of tridentate Schiff base ligands [VO(OMe)L'] (1), [VO(OMe)L2] (2) and [VO(OMe)L3] (3) obtained by monocondensation of 3-hydroxy-2-naphthohydrazide and aromatic o-hydroxyaldehydes have been synthesized (H2L2 - (E)-3-hydroxy-N′-(2-hydroxy-3-methoxybenzylidene)-2-naphthohydrazide, H2L2 - (E)-3-hydroxy-N′-(2-hydroxybenzylidene)-2- naphthohydrazide and H2L3 - (E)-N′-(5-bromo-2- hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide). The complexes were characterized by spectroscopic methods in the solid state (IR) and in solution (UV-Vis, 1H NMR). Single crystal X-ray analyses were performed with 1 and 2. The catalytic potential of these complexes has been tested for the oxidation of cyclooctene using H2O2 as the terminal oxidant. The effects of various parameters including the molar ratio of oxidant to substrate, the temperature, and the solvent have been studied. The catalyst 2 showed the most powerful catalytic activity in oxidation of various terminal, cyclic and phenyl substituted olefins. Excellent conversions have been obtained for the oxidation of cyclic and bicyclic olefins.

COMPLEXES OF Co(II), Ni(II) AND Zn(II) WITH 3-HYDROXY-2-NAPHTHOYL HYDRAZONES OF SOME AROMATIC ALDEHYDES

3-Hydroxy-2-naphthoyl hydrazones of benzaldehyde, p-chlorobenzaldehyde, p-nitrobenzaldehyde, vaniline, o-vaniline and salicylaldehyde together with their metal complexes have been prepared.All compounds have been characterized by chemical analysis and i.r