80653-81-2

Upstream product

• 77409-99-5 4-(pyridin-4-yl)phenol 
• 4394-03-0 4-(4-methoxy-3-nitrophenyl)pyridine 
• 110-86-1 pyridine 
• 13296-04-3 4-(pyridin-4-yl)aniline 
• 104-94-9 4-methoxy-aniline 
• 5938-16-9 4-(4-methoxylphenyl)pyridine 

Downstream Products

• 158461-39-3 4-[3-Nitro-4-(2,2,2-trifluoro-ethoxy)-phenyl]-pyridine 
• 158461-96-2 {1-Methyl-2-[5-pyridin-4-yl-2-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 158461-66-6 5-Pyridin-4-yl-2-(2,2,2-trifluoro-ethoxy)-phenylamine 
• 80653-84-5 2-amino-4-(pyridin-4-yl)phenol 

Relevant academic research and scientific papers

HETEROCYCLIC KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative

A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.