13296-04-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(Pyridin-4-yl)aniline is used as a chemical intermediate for the synthesis of 2-Amino-4-(4-pyridyl)phenol, a compound that can increase cardiac contractility. This makes it a valuable component in the development of medications for heart-related conditions.
Used in Chemical Research:
4-(Pyridin-4-yl)aniline is derived from 4-Pyridineboronic Acid, a boronic acid derivative known for its binding affinities with diols. This property makes it useful in chemical research, particularly in the development of new compounds and materials with specific binding properties.

InChI:InChI=1/C11H10N2/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-8H,12H2

Upstream product

• 93830-58-1 diethyl (pyridin-4-yl)borane 
• 540-37-4 p-aminoiodobenzene 
• 19524-06-2 4-bromopyridine hydrochloride 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 636-98-6 p-nitrobenzene iodide 
• 586-78-7 para-nitrophenyl bromide 
• 181219-01-2 4-pyridineboronic acid pinacol ester 
• 1692-15-5 4-pyridylboronic acid 
• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 330793-01-6 (4-tert-butoxycarbonylaminophenyl)boronic acid pinacol ester 
• 59656-60-9 N-(4-(pyridin-4-yl)phenyl)acetamide 
• 214360-60-8 N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 106-40-1 4-bromo-aniline 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 111065-56-6 N-(4-ethoxy-phenyl)-N'-(4-[4]pyridyl-phenyl)-thiourea 
• 124104-52-5 N-(4-butoxy-phenyl)-N'-(4-[4]pyridyl-phenyl)-thiourea 
• 59656-60-9 N-(4-(pyridin-4-yl)phenyl)acetamide 
• 113682-56-7 1,4-bis(4-pyridyl)benzene 
• 113682-55-6 1-(2-pyridyl)-4-(4-pyridyl)benzene 
• 83420-59-1 4-(4'-iodophenyl)pyridine 
• 77409-92-8 4-(4'-pyridyl)phenyl 4''-n-hexyloxybenzoate 
• 77409-93-9 4-(4'-pyridyl)phenyl 4''-n-heptyloxybenzoate 
• 77409-94-0 4-(4'-pyridyl)phenyl 4''-n-octyloxybenzoate 
• 77409-95-1 4-(4'-pyridyl)phenyl 4''-n-nonyloxybenzoate 
• 77409-97-3 4-(4'-pyridyl)phenyl 4''-n-dodecyloxybenzoate 
• 77409-98-4 4-(4'-pyridyl)phenyl 4''-n-tetradecyloxybenzoate 
• 861024-61-5 4-([1,1’-biphenyl]-4-yl)pyridine 

Relevant academic research and scientific papers

Optically sensed, molecular shuttles driven by acid-base chemistry

A pair of bistable [2]rotaxane, molecular shuttles were prepared that combine 1,2-bis(pyridinium)ethane and benzylanilinium recognition sites; acid-base controlled shuttling of DB24C8 was accompanied by a change in colour and/or fluorescence intensity. The Royal Society of Chemistry.

Functionalized naphthalenediimide based supramolecular charge-transfer complexesviaself-assembly and their photophysical properties

We report here the design and syntheses of a naphthalenediimide (NDI)-N functionalized organic fluorophore,1, and its supramolecular CT complexes [(1·2H)2+·(PA?)2] (2) and [(1·2H)2+·(3,5-DNSA?)2] (3), self-assembled from1as an electron acceptor (A) and picric acid (PA) or 3,5-dinitrosalicylic acid (3,5-DNSA) as a donor (D), with a very large Stokes shift (>170 nm) and significant fluorescence lifetime (～1.55 ns). NDI is functionalized with phenylpyridyl units (chromophore) to extend the π-conjugation and thus provide a suitable platform for strong C-H-π and π?π stacking interactions, which are the prime requirements for any compound to be used as a fluorescent probe. The organic fluorophore,1, and its supramolecular CT complexes2and3exhibit decent electronic properties as suggested by DFT, cyclic voltammetry, and fluorescence studies. Moreover, compounds1-3were also exploited as fluorescent probes for cell imaging under normal cell isolation and with time-bound exposure.

Electron transfer within self-assembling cyclic tetramers using chlorophyll-based donor-acceptor building blocks

The synthesis and photoinduced charge transfer properties of a series of Chl-based donor-acceptor triad building blocks that self-assemble into cyclic tetramers are reported. Chlorophyll a was converted into zinc methyl 3-ethylpyrochlorophyllide a (Chl) and then further modified at its 20-position to covalently attach a pyromellitimide (PI) acceptor bearing a pyridine ligand and one or two naphthalene-1,8:4,5-bis(dicarboximide) (NDI) secondary electron acceptors to give Chl-PI-NDI and Chl-PI-NDI2. The pyridine ligand within each ambident triad enables intermolecular Chl metal-ligand coordination in dry toluene, which results in the formation of cyclic tetramers in solution, as determined using small- and wide-angle X-ray scattering at a synchrotron source. Femtosecond and nanosecond transient absorption spectroscopy of the monomers in toluene-1% pyridine and the cyclic tetramers in toluene shows that the selective photoexcitation of Chl results in intramolecular electron transfer from 1*Chl to PI to form Chl+?-PI -?-NDI and Chl+?-PI-?-NDI 2. This initial charge separation is followed by a rapid charge shift from PI-? to NDI and subsequent charge recombination of Chl+?-PI-NDI-? and Chl+?-PI- (NDI)NDI-? on a 5-30 ns time scale. Charge recombination in the Chl-PI-NDI2 cyclic tetramer (τCR = 30 ± 1 ns in toluene) is slower by a factor of 3 relative to the monomeric building blocks (τCR = 10 ± 1 ns in toluene-1% pyridine). This indicates that the self-assembly of these building blocks into the cyclic tetramers alters their structures in a way that lengthens their charge separation lifetimes, which is an advantageous strategy for artificial photosynthetic systems.

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof

The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.

RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AS WELL AS PREPARATION METHOD AND USE THEREOF

The present invention relates to a Rho-associated protein kinase inhibitor of Formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for the prevention or treatment of a disease mediated by the Rho-associated protein kinase (ROCK).

RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AS WELL AS PREPARATION METHOD AND USE THEREOF

The present invention relates to a Rho-associated protein kinase inhibitor of Formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for the prevention or treatment of a disease mediated by the Rho-associated protein kinase (ROCK).

Microballs Containing Ni(0)Pd(0) Nanoparticles for Highly Selective Micellar Catalysis in Water

Both Ni(0) complexes and nanoparticles (NPs) are unstable in water, which poses a significant hindrance to their application in aqueous synthetic catalysis. To overcome these barriers, ligated Ni(0) nanoparticles (diameter 1 nm) containing a minimum amount of Pd(0) in the microballs formed of amphiphile PS-750-M are developed and applied in the highly selective carbamate cleavage. Selectivity and functional group tolerance are thoroughly investigated. Control experiments revealed the importance of an individual component of the nanocatalyst. Use of our proline-based amphiphile PS-750-M is critical for achieving microball architecture, the stability of nanoparticles, and desired catalytic activity. Once formed, microballs can be isolated and stored at ambient temperature. Catalyst is thoroughly characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy, thermogravimetric analysis, infrared, and cyclic voltammetry. For selective catalysis, zero oxidation state of both Ni and Pd is crucial. On the basis of catalyst characterization and control experiments, the plausible reaction mechanism is proposed.

Triazole naphthoquinone connected aromatic (heterocyclic) ring derivative

The invention belongs to the field of chemical medicine, particularly relates to a micromolecule capable of resisting malignant tumor, acute leukemia and arthritis, multiple sclerosis and immunological rejection and a preparation and application of the mi

The synthesis of a rigid conjugated viologen and its cucurbituril pseudorotaxanes

A linear viologen (bis[4-(4-pyridinyl)phenyl] viologen, BPPV) characterized by a fully-conjugated structure was synthesized through Zinke reaction. BPPV consists of a unique linear sexiaryl structure and is apt to be encapsulated by cucurbit[n]uril (CB[n]