80663-95-2

Usage

Uses

Used in Pharmaceutical Industry:
CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL] is used as a demethylating and oxidizing agent for membrane-associated DNA. Its ability to modify DNA structure makes it a valuable tool in the development of new drugs and therapies.
Used in Antiviral Research:
In the field of antiviral research, CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL] has been employed to develop a cell-based high-throughput screening assay. This assay is designed to identify potential anti-hepatitis C virus compounds, contributing to the discovery of new treatments for this viral infection.
Used in Chemical Synthesis:
Due to its unique structure and reactivity, CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL] can be utilized in chemical synthesis processes. It may serve as a building block or intermediate in the production of various pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Analytical Chemistry:
CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL]'s distinctive properties also make it suitable for use in analytical chemistry. It can be employed as a reagent or standard in various analytical techniques, such as chromatography, mass spectrometry, or spectrophotometry, to analyze and identify other compounds.

InChI:InChI=1/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)

Upstream product

• 696-40-2 3-iodobenzylamine 
• 3674-54-2 tetrabutylammonium thiocyanate 
• 14527-26-5 2-methylisothiourea sulphate 
• 103346-17-4 m-iodobenzylguanidine dihydrogen carbonate 
• 50-01-1 guanidine hydrochloride 
• 49617-83-6 m-Iodobenzyl bromide 

Downstream Products

• 1207623-53-7 N-(3-iodobenzyl)-N'-(3-carbonyl-quinoline)guanidine 
• 77679-27-7 [¹³¹I]-meta-iodobenzylguanidine 

Relevant academic research and scientific papers

Fully Automated Radiosynthesis of [11C]Guanidines for Cardiac PET Imaging

Radiolabeled guanidines such as meta-iodobenzylguanidine (MIBG) find utility in nuclear medicine as both diagnostic imaging agents and radiotherapeutics and, over the years, numerous methods for incorporating radionuclides into guanidines have been develo

MIBG ANALOGS AND USES THEREOF

Compounds and compositions for targeting cells expressing norepinephrine transporter, and methods of making and using the same. The compounds comprise MIBG analogs conjugated to active agents for treatment and/or diagnosis of various conditions, including neuroblastoma.

Radioactive iodine labeling method

The invention discloses a radioactive iodine labeling method. Ar-B(OH)2 is allowed to react with NaI in a reaction solvent in the presence of a copper coordination compound so as to obtain Ar-I, so radioactive iodine labeling is realized. The method

A Highly Efficient Copper-Mediated Radioiodination Approach Using Aryl Boronic Acids

A convenient and quantitative radioiodination method by copper-mediated cross-coupling of aryl boronic acids was developed. The mild labeling conditions, ready availability of the boronic acid substrate, simple operation, broad functional group tolerance and excellent radiochemical yield (RCY) make this a practical strategy for radioiodine labeling without further purification.

A convenient method for the preparation of radioiodinated meta-iodobenzylguanidine at a no-carrier-added level

Radioiodinated meta-iodobenzylguanidine (MIBG) in high effective specific activity was prepared using 3-tributylstannylbenzylguanidine as the precursor. The labeling was carried out in aqueous solution with the insoluble and lyophilized precursor suspende

STABILIZATION OF RADIOIODINATED AND ASTATINATED PHARMACEUTICALS AND IMAGING AGENTS

Provided herein are stabilized radioiodinated and astatinated compounds, and to methods for their preparation.

Chemical delivery system of metaiodobenzylguanidine (MIBG) to the central nervous system

The aim of the present investigation was to apply a chemical delivery system (CDS) to MIBG(4) with the purpose of delivering this drug to the CNS. Compound 4 has been linked to a 1,4-dihydroquinoline moiety in order to achieve its CNS penetration, and here we report the synthesis to link 4 to the chemical delivery system and the radiosynthesis with carbon-11 of the CDS-4 entity . After iv injection into rats of the [11C]CDS-4, the follow-up study of the radioactivity distribution in blood samples and brain homogenates and the analysis by HPLC and LC-MS/MS have confirmed the release of 4 into the CNS.

A traceless linker approach to the solid phase synthesis of substituted guanidines utilizing a novel acyl isothiocyanate resin

Solid phase synthesis of a series of substituted guanidines based on a novel acyl isothiocyanate resin is presented. This method provides both mono and disubstituted guanidines with a variety of sterically demanding and/or electron withdrawing substituents in good purities and yields.

Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound

The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an inactive carrier and/or one or more auxiliary substances, wherein the hydrogen containing compound comprises at least one deuterium atom. The invention further relates to a compound to be used for said composition and to a kit for preparing a radio-diagnostic composition.

Imaging agent and method of use

A new radiopharmaceutical composition for use in nuclear medicine comprises a radioiodinated meta-iodobenzylguanidine. The composition is used as an imaging agent for the heart, adrenal medulla, and tumors of the adrenal medulla and can be used for treatm