80676-54-6

Usage

Uses

Used in Medicinal Chemistry:
2-(butan-2-yl)-1,4,5,6-tetrahydropyrimidine is used as a chemical compound in medicinal chemistry for its potential pharmacological properties. The butan-2-yl substitution may enhance its biological activity, making it a candidate for further research and development in drug discovery.
Used in Drug Discovery:
In the pharmaceutical industry, 2-(butan-2-yl)-1,4,5,6-tetrahydropyrimidine is used as a lead compound for the development of new drugs. Its unique structure and potential biological activities suggest that it could be optimized for specific therapeutic applications, pending further research into its effects and mechanisms of action.
Further research is necessary to fully understand the potential uses and effects of 2-(butan-2-yl)-1,4,5,6-tetrahydropyrimidine, as its diverse biological activities and the influence of the butan-2-yl group on its properties are not yet fully explored.

Upstream product

• 80676-51-3 3-(3-aminopropylamino)-4-methylhex-2-enenitrile 
• 113518-25-5 (E)-3-(3-hydroxypropylamino)-4-methylhex-2-enenitrile 
• 80676-56-8 4,8-diaza-3,9-di(1-methylpropyl)undeca-2,9-diene-1,11-dinitrile 

Relevant academic research and scientific papers

Allenes. Part 45. 2-Alkyltetrahydropyrimidines, 2-Alkylidenetetrahydro-2H-1,3-oxazines, 2-Alkyl-5,6-dihydro-4H-1,3-oxazines and 2-Alkyl-3-cyano-1,4,5,6-tetrahydropyridines from Allenic nitriles.

The synthesis of 2-alkyl-3,4,5,6-tetrahydropyrimidines, 2-alkylidene-3,4,5,6-tetrahydro-2H-1,3-oxazines, 2-alkyl-5,6-dihydro-4H-1,3-oxazines and 2-alkyl-3-cyano-1,4,5,6-tetrahydropyridines from allenic nitriles is described.Spectroscopic evidence and mechanistic pathways are discussed.

Allenes. Part 40. 2:1 Bis-adducts from Allenic Nitriles and Phenylpropynenitriles with Difunctional Nucleophiles and their Conversion into Heterocycles

Two equivalents of allenic nitrile or phenylpropynenitrile add to 1,2- and 1,3-diamines, 2-aminoethanethiol, ethanedithiol, and 4-aminopyridine to give 2:1 adducts of structure (2), (4), and (5).Ring closure and elimination of one equivalent each of allenic nitrile (or phenylpropynenitrile) and acetonitrile gave the imidazolines (29), the thiazolines (30), and the tetrahydropyrimidines (31).Mass spectral fission patterns are discussed.

NOVEL SYNTHESES OF DIHYDROOXAZINES, TETRAHYDROPYRIMIDINES AND TETRAHYDROPYRIDINES FROM ALLENYL NITRILES

α-Allenylnitriles give dihydrooxazines and tetrahydropyridines with 3-hydroxypropylamine whereas with 1,3-diaminopropane they afforded tetrahydropyrimidines.