80683-81-4Relevant academic research and scientific papers
A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination
Tang, Yu,Yu, Biao
, (2022/03/27)
A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.
SYNTHESIS OF THE RACEMIC ALKALOID DIPTALINE
Tolstikov, A. G.,Biktimirova, L. A.,Tolstikova, O. V.,Shmakov, V. S.,Vyrypaev, E. M.,Tolstikov, G. A.
, p. 85 - 87 (2007/10/02)
The isolation from the plant Dipthychocarpus strictus (Cruciferae) of the optically active base diptaline, identified as N-(11-methylsulfinylundecyl)urea, has been reported .A synthesis of the racemic form of this alkaloid has now been achieved.
