80705-13-1

Usage

Uses

Used in Industrial Applications:
2H,2H,3H,3H-Perfluoroheptanoic acid is used as a surfactant in the production of non-stick cookware and water-repellent fabrics due to its unique properties.
Used in Environmental and Health Research:
PFHpA is a subject of research due to its persistence in the environment and potential health effects. Studies have linked exposure to PFHpA with adverse effects on liver function, immune system, and development in animals, and there is growing evidence of similar risks in humans.
Used in Regulatory Efforts:
Efforts are being made to regulate and phase out the use of PFHpA and other PFCs in various products to protect human health and the environment, given the concerns about their persistence and potential adverse effects.

Upstream product

• 19430-93-4 3,3,4,4,5,5,6,6,6-Nonafluoro-1-hexene 
• 201230-82-2 carbon monoxide 
• 2043-55-2 3,3,4,4,5,5,6,6,6-nonafluorohexyliodide 
• 124-38-9 carbon dioxide 
• 130361-59-0 4,4,5,5,6,6,7,7,7-nonafluoroheptanecarbonitrile 
• 136905-37-8 Ethyl 4,4,5,5,6,6,7,7,7-nonafluoroheptanoate 

Relevant academic research and scientific papers

Synthesis of Carboxylic Acids by Palladium-Catalyzed Hydroxycarbonylation

The synthesis of carboxylic acids is of fundamental importance in the chemical industry and the corresponding products find numerous applications for polymers, cosmetics, pharmaceuticals, agrochemicals, and other manufactured chemicals. Although hydroxycarbonylations of olefins have been known for more than 60 years, currently known catalyst systems for this transformation do not fulfill industrial requirements, for example, stability. Presented herein for the first time is an aqueous-phase protocol that allows conversion of various olefins, including sterically hindered and demanding tetra-, tri-, and 1,1-disubstituted systems, as well as terminal alkenes, into the corresponding carboxylic acids in excellent yields. The outstanding stability of the catalyst system (26 recycling runs in 32 days without measurable loss of activity), is showcased in the preparation of an industrially relevant fatty acid. Key-to-success is the use of a built-in-base ligand under acidic aqueous conditions. This catalytic system is expected to provide a basis for new cost-competitive processes for the industrial production of carboxylic acids.

Synthesis and surface properties of new semi-fluorinated sulfobetaines potentially usable for 2D-electrophoresis

New semi-fluorinated amidosulfobetaines, homologs of hydrocarbon amidosulfobetaines (ASB) commonly used in two-dimensional gel electrophoresis (2DE), were prepared in three steps from 2-F-alkylethyl iodide or F-alkyl iodide. Their synthesis was described and their air-water interface properties were investigated and compared with their perhydrogenated counterpart properties. The influence of the relative lengths of the perfluorinated and hydocarbonated moieties was discussed. 2DE of a rat testicular membrane fraction was performed comparatively using one of these fluorinated sulfobetaines and its hydrocarbon homolog; these preliminary results showed the great potential of the semi-fluorinated sulfobetaines in proteomic analysis.

Preparation and liquid crystalline behaviour of a series of semifluorinated allylic monomers

A series of smectic liquid-crystalline 4,4'-biphenyl derivatives incorporating a perfluorinated segment and an allylic part have been prepared and their mesomorphic properties investigated. The preparation of these compounds has been done from 2-F-butylethyl iodide, the 2-F-hexylethyl iodide or the 2-F-octylpropanoic acid. The physical properties of these novel fluorinated materials are commented and illustrated in comparison with four homologous allylic series previously described. The choice of the molecular design of these monomers allows us to obtain dimorphism and high mesomorphic range determined from differential thermal analysis and the light microscopy.

3-methyl-chroman and -thiochroman derivatives

The present invention provides a compound having the following general formula (1): in which R1represents a hydrogen atom, etc.; R2represents a C3-C3perhalogenoalkyl group, etc.; each of R3and R4independently represents a hydrogen atom, etc.; X represents an oxygen atom or a sulfur atom; m represents an integer of 2 to 14; and n represents an integer of 0 to 8; or enantiomers of the compound, or hydrates or pharmaceutically acceptable salts of the compound or its enantiomers. The compound of general formula (1) is advantageous in pharmaceutical use because of its anti-estrogenic activity.

Absolute rate constants for radical additions to alkenes in solution. The synergistic effect of perfluorination on the reactivities of n-alkyl radicals

Laser flash photolysis has been used to determine the absolute rate constants for addition of several partially fluorinated n-alkyl radicals to three styrenes at 25°C in Freon 113. Fluorination at the γ-position (RCF2CH2CH2?) gives radicals with essentially the same reactivity as non-fluorinated n-alkyls. The RCH 2CF2CH2? and RCH2CH 2CHF? radicals are both about three times as reactive as RCF2CH2CH2?, but the RCH 2CH2CF2? radical is ca. five to six times rather than ca. three times as reactive as RCH2CH2CHF?. Similarly, the perfluorinated radical CF3CF2CF 2? is much more reactive than would be expected on the basis of the reactivities of the RCH2CF2CH2? and RCH2CH2CF2? radicals. Thus, perfluorinated n-alkyl radicals are very considerably more reactive than would be predicted from the individual effects of α, β-, and γ-fluorination.

Synthese des isocyanates de 2-F-alkylethyle

Isocyanates are extremely important compounds in organic synthesis but their preparation is not always easy.One of the most convenient methods uses the acids as intermediates.In the F-alkyl series it is sometimes difficult to obtain them.We have optimized an efficient synthetic route to 2-F-alkylethyl isocyanates.