80708-33-4

Upstream product

• 87885-14-1 N'-(6-Chloro-3-oxo-4-propyl-3,4-dihydro-quinoxalin-2-yl)-hydrazinecarboxylic acid ethyl ester 
• 1246738-34-0 3-Chloro-1-methyl-2-oxo-1,2-dihydro-quinoxaline-6-carboxylic acid methyl ester 
• 92473-55-7 methyl 1-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate 
• 66315-16-0 methyl 3-amino-4-(methylamino)benzoate 

Downstream Products

• 90042-36-7 7-Chloro-2-[(E)-(3-phenyl-acryloyl)]-5-propyl-2H,5H-[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dione 

Relevant academic research and scientific papers

1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents

A series of new 1,4-dihydro-1,2,4-triazolo[4,3-a]quinoxaline-1,4-diones has been reported. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated rat passive cutaneous anaphylaxis (PCA). Most of this new class of antiallergic agents showed good activity in the RMC and PCA tests. The most potent compound, 2-acetyl-7-chloro-5-n-propyl-1,2,4-triazolo[4,3-a]quinoxaline-1,4-dione, with an I50 value of 0.1 μM, is 30 times more potent than disodium cromoglycate (DSCG) in the RMC assay.