92473-55-7

Basic information

• Product Name: Methyl 1-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate
• Synonyms: Methyl 1-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate
• CAS NO: 92473-55-7
• Molecular Formula: C11H10N2O4
• Molecular Weight: 234
• Mol File: 92473-55-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 1-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate(92473-55-7)
• EPA Substance Registry System: Methyl 1-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate(92473-55-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 92473-55-7(Hazardous Substances Data)

Upstream product

• 1448363-21-0 methyl 1-methyl-2-oxo-1,2-dihydroquinoxaline-6-carboxylate 
• 79-37-8 oxalyl dichloride 
• 66315-16-0 methyl 3-amino-4-(methylamino)benzoate 

Downstream Products

• 90042-36-7 7-Chloro-2-[(E)-(3-phenyl-acryloyl)]-5-propyl-2H,5H-[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dione 
• 80708-33-4 7-Chloro-5-propyl-2H,5H-[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dione 
• 1246738-34-0 3-Chloro-1-methyl-2-oxo-1,2-dihydro-quinoxaline-6-carboxylic acid methyl ester 

Relevant articles and documents

Green synthesis method of N-substituted-1,4-dihydro-2,3-quinoxalinedione compound

The invention discloses a green synthesis method of an N-substituted-1,4-dihydro-2,3-quinoxalinedione compound. The green synthesis method comprises the following steps: reacting ammonium persulfate with an N-substituted quinoxaline-2(1H)-one derivative in an aqueous solution of DL-alpha-tocopherol methoxy polyethylene glycol succinic acid water to generate the N-substituted-1,4-dihydro-2,3-quinoxalinedione compound; and after the reaction is finished, extracting a reaction product by using ethyl acetate, and performing vacuum drying to obtain the high-purity target product. The aqueous solution of the DL-alpha-tocopherol methoxy polyethylene glycol succinic acid can be recycled at least five times or more. The method is good in product selectivity, high in yield, simple in separation process, low in raw material cost, friendly to environment and beneficial for industrial production and application.

1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents

A series of new 1,4-dihydro-1,2,4-triazolo[4,3-a]quinoxaline-1,4-diones has been reported. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated rat passive cutaneous anaphylaxis (PCA). Most of this new class of antiallergic agents showed good activity in the RMC and PCA tests. The most potent compound, 2-acetyl-7-chloro-5-n-propyl-1,2,4-triazolo[4,3-a]quinoxaline-1,4-dione, with an I50 value of 0.1 μM, is 30 times more potent than disodium cromoglycate (DSCG) in the RMC assay.