80709-78-0

Usage

Uses

Used in Dye Synthesis:
Ethyl 2-methyl-4H-furo[3,2-b]pyrrole-5-carboxylate is used as a key intermediate in the synthesis of dyes with near-infrared (NIR) fluorescent optical properties. These dyes have a wide range of applications, including bioimaging, sensing, and phototherapy, due to their unique optical characteristics and ability to absorb and emit light in the NIR region.
Used in Bioimaging Applications:
In the field of bioimaging, Ethyl 2-methyl-4H-furo[3,2-b]pyrrole-5-carboxylate-based dyes are employed as contrast agents for visualizing biological structures and processes. Their NIR fluorescence allows for deep tissue penetration and reduced photobleaching, making them suitable for long-term imaging studies.
Used in Sensing Applications:
Ethyl 2-methyl-4H-furo[3,2-b]pyrrole-5-carboxylate-based dyes can also be used in sensing applications, where they can detect and respond to specific analytes or environmental changes. Their NIR fluorescence properties enable remote sensing and minimize interference from background signals, improving the sensitivity and selectivity of the detection process.
Used in Phototherapy Applications:
In phototherapy, Ethyl 2-methyl-4H-furo[3,2-b]pyrrole-5-carboxylate-based dyes can be utilized as photosensitizers for the treatment of various conditions, such as cancer and bacterial infections. Their ability to absorb light in the NIR region allows for targeted delivery and activation, reducing side effects and improving treatment outcomes.
Overall, Ethyl 2-methyl-4H-furo[3,2-b]pyrrole-5-carboxylate is a versatile compound with a wide range of potential applications in various industries, particularly in the development of advanced materials and technologies with NIR fluorescent properties.

InChI:InChI=1/C10H11NO3/c1-3-13-10(12)8-5-9-7(11-8)4-6(2)14-9/h4-5,11H,3H2,1-2H3

Upstream product

• 620-02-0 5-Methylfurfural 
• 637-81-0 ethyl-2-azidoacetate 
• 80709-72-4 Ethyl 2-azido-3-(5-methyl-2-furyl)acrylate 

Downstream Products

• 80709-80-4 2-Methyl-4H-furo<3,2-b>pyrrole-5-carboxylic acid 
• 144658-78-6 2-Methyl-4-(4-nitro-benzyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 238749-01-4 Ethyl 4-(3,4-dichlorobenzyl)-2-methylfuro[3,2-b ]pyrrole-5-carboxylate 
• 80709-81-5 2-Methyl-4-ethylfuro<3,2-b>pyrrole-5-carboxylic acid 
• 132120-23-1 2-methyl-4-acetylfuro<3,2-b>pyrrole 
• 144658-79-7 2-Methyl-4-(2-nitro-benzyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

FLUORESCENT COMPOUND AND LABELING AGENT COMPRISING THE SAME

A novel fluorescent compound having a high light fastness, high fluorescence quantum yield and sharp absorption spectrum, which emits fluorescence having a wavelength in long wavelength region, as well as its use as a labeling agent, is disclosed. In Form

Bright, color-tunable fluorescent dyes in the Vis/NIR region: Establishment of new "tailor-made" multicolor fluorophores based on borondipyrromethene

A new series of high-performance fluorophores named Keio Fluors (KFL), which are based on borondipyrromethene (BODIPY), are reported. The KFL dyes cover a wide spectral range from the yellow (547 nm) to the near-infrared (NIR, 738 nm) region, and their emission wavelength could be easily and subtly controlled based on simple molecular modifications only, without losing their optical properties. This "tailor-made" synthetic strategy for tuning the emission wavelength enabled the creation of fourteen KFL dyes with well-controlled emission colors (yellow, orange, red, far-red, and NIR). Moreover, these KFL dyes also retain their excellent optical properties, such as spectral bands sharper than quantum dots, high extinction coefficients (140000-316000 M-1 cm-1), and high quantum yields (0.56-0.98), without any critical solvent polarity dependent decrease of their brightness. These advantageous characteristics make the KFL dyes potentially useful as new candidates of fluorescent standard dyes to substitute or to complement existing long-wavelength fluorescent dyes, such as cyanines, oxazines, rhodamines, or other BODIPY dyes.

Bright, color-tunable fluorescent dyes in the visible-near-infrared region

The newly synthesized Keio Fluors, which are based on boron-dipyrromethene (BDP), have excellent and useful optical properties: vivid colors and sharp emission in the visible-near-infrared region (583-738 nm), high quantum yields (Φ: 0.56-0.98), high exti

Heterocyclic compounds

Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.

SYNTHESIS AND REACTIONS OF SUBSTITUTED FUROPYRROLE DERIVATIVES

Preparation of ethyl 2-methylfuropyrrole-5-carboxylate and 2-bromofuropyrrole-5-carboxylate, as well as alkylation and hydrolysis of ethyl 2-methylfuropyrrole-5-carboxylate, ethyl furopyrrole-5-carboxylate and ethyl (3,4-dichlo