80710-76-5

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 80710-70-9 1-o-Tolyl-1,2,3,4-tetrahydro-[1]naphthol 
• 22718-24-7 3,4-dihydronaphthalen-1-yl dimethylcarbamate 
• 6699-93-0 (2-methylphenyl)lithium 

Downstream Products

• 102018-47-3 acetic acid-(1-o-tolyl-3,4-dihydro-[2]naphthyl ester) 
• 82-05-3 7H-benz[d,e]anthracene-7-one 
• 108973-37-1 3-nitro-4-o-tolyl-1,2-dihydro-naphthalene 
• 14476-01-8 1-o-tolylnaphthalene 

Relevant academic research and scientific papers

Pd-catalyzed cross-coupling of highly sterically congested enol carbamates with grignard reagents via c-o bond activation

The palladium-catalyzed cross-coupling reaction of enol carbamates to construct highly sterically congested alkenyl compounds is presented for the first time. This protocol demonstrates the potential of using thermally stable and highly atom-economic enol electrophiles as building blocks in bulky alkene synthesis. This reaction accommodates a broad substrate scope with excellent Z/E isomer ratios, which also provides a new synthetic pathway for accessing Tamoxifen.

Conversion of Carbonyl Compounds to Olefins via Enolate Intermediate

A general and efficient protocol to synthesize substituted olefins from carbonyl compounds via nickel catalyzed C—O activation of enolates was developed. Besides ketones, aldehydes were also suitable substrates for the presented catalytic system to produce di- or tri- substituted olefins. It is worth noting that this approach exhibited good tolerance to highly reactive tertiary alcohols, which could not survive in other reported routes for converting carbonyl compounds to olefins. This method also showed good regio- and stereo-selectivity for olefin products. Preliminary mechanistic studies indicated that the reaction was accomplished through nickel catalyzed C—O activation of enolates, thus offering helpful contribution to current enol chemistry.

Solid phase synthesizing method of dihydronaphthalene compound

A solid phase synthesizing method of a dihydronaphthalene compound I belongs to the field of organic chemistry and comprises: 1, using 1% crosslinked polystyrene resin as a carrier to prepare a polystyrene-loaded selenium base succinimide reagent III; 2, under catalyzing of fluoroform sulfonic acid trimethyl estersil, using the III to induce olefin V to be subjected to intramolecular cyclization to form 3-polystyrene-loaded selenium base-1,2,3,4-tetrahydronaphthalene VI; 3, removing VI by an oxidant through oxidation without further separating, thereby directly obtaining dihydronaphthalene I. Raw materials are easy to obtain, the product yield is good, the purity is high, the operation is simple and convenient, the posttreatment is simple and the method has well industrial application prospect.

A mild dihydrobenzooxaphosphole oxazoline/iridium catalytic system for asymmetric hydrogenation of unfunctionalized dialins

Air-stable P-chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium-catalyzed asymmetric hydrogenation of unfunctionalized 1-aryl-3,4-dihydronaphthalenes under one atmosphere pressure of H2, up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1-tetralones.