807330-07-0Relevant academic research and scientific papers
Stereoselective preparation of functionalized acyclic alkenylmagnesium reagents using i-PrMgCl-LiCl
Ren, Hongjun,Krasovskiy, Arkady,Knochel, Paul
, p. 4215 - 4217 (2004)
(Chemical Equation Presented) Acyclic functionalized alkenyl iodides are converted with high stereoselectivity to the corresponding functionalized alkenylmagnesium derivatives by the reaction with i-PrMgCl-LiCl between -40 and -20°C. Functional groups such as a nitrile, chloride, iodide, and ester are readily tolerated. The conversion of an alkenyl iodide bearing a keto group to the corresponding silylated cyanohydrin allows preparation of the corresponding Grignard reagent affording, after acylation and deprotection, unsaturated 1,4-diketones.
