807366-09-2

Upstream product

• 807366-03-6 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-tert-butyldiphenylsilyloxyethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxy-3-(2-trimethylsilylethoxy)methoxyheptadec-16-ene 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 807365-74-8 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-tert-butyldiphenylsilyloxyethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxy-16-(4-methoxybenzyloxy)hexadecan-3-ol 
• 807365-58-8 (E)-(2S,10R)-2-Benzyloxy-1-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-8-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-10-hydroxy-11-(4-methoxy-benzyloxy)-3,3-dimethyl-undec-5-en-4-one 
• 807365-96-4 6-{4-benzyloxy-6-[4-(tert-butyl-diphenyl-silanyloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-2-ylmethyl}-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-tetrahydro-pyran-2-carbaldehyde 
• 807365-65-7 (S)-4-Benzyloxy-5-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-1-[(2S,6R)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-6-(4-methoxy-benzyloxymethyl)-tetrahydro-pyran-2-yl]-3,3-dimethyl-pentan-2-one 
• 807365-88-4 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-tert-butyldiphenylsilyloxyethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxy-3-(2-trimethylsilylethoxy)methoxyhexadecan-16-ol 
• 807365-81-7 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-tert-butyldiphenylsilyloxyethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxy-16-(4-methoxybenzyloxy)-3-(2-trimethylsilylethoxy)methoxyhexadecane 

Relevant academic research and scientific papers

A stereoselective synthesis of the C(1)-C(16) fragment of the bryostatins

A synthesis of the C(1)-C(16) fragment of the brysostatins has been developed. Key steps are the stereoselective copper(I) catalysed addition of allylmagnesium bromide to an alkynyl ester, a condensation of a βγ-unsaturated aldehyde with a ketophosphonate