80743-36-8

Upstream product

• 110-91-8 morpholine 
• 28030-16-2 3-(4-methoxyphenyl)-2-oxopropanoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 6303-59-9 (E)-4-(2-bromo-vinyl)-anisole 

Downstream Products

• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 84569-62-0 C₂₁H₂₆N₂O 

Relevant academic research and scientific papers

B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of: In situ -formed enamines

A highly efficient B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective β-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)3 could activate water to promote the protonation and reduction of enamines. This journal is

Multicomponent and one-pot synthesis of trisubstituted pyridines through a Pd-catalyzed cross-coupling/cross-coupling/cycloaddition sequence

Trisubstituted pyridines are regioselectively synthesized through multicomponent and one-pot processes promoted by a bifunctional Pd-catalyst. The process involves formation of an enamine by Pd-catalyzed amination of an alkenyl bromide, formation of a 2-aza-1,3-butadiene by Pd-catalyzed cross-coupling of a trimethylsilylimine with an alkenyl bromide, and Lewis acid catalyzed cycloaddition between the enamine and the azadiene.

ALDEHYDE-ENAMINES FROM α-OXOCARBOXYLIC ACIDS. A FACILE AND GENERAL ROUTE TO ALDEHYDES VIA DECARBOXYLATION OF α-OXOCARBOXYLIC ACIDS CARRYING β-HYDROGENS

When α-oxocarboxylic acids carrying β-hydrogens are treated with a secondary amine in boiling benzene with azeotropic removal of water, they decarboxylate quantitatively to form aldehyde-enamines which subsequently are hydrolyzed to the corresponding aldehydes in high yields.