80745-61-5

Upstream product

• 773-34-2 4-methoxybicyclo<2.2.2>octane-1-carboxylic acid 
• 108-24-7 acetic anhydride 
• 74467-18-8 4-Iodo-1-bicyclo<2.2.2>octyl Methyl Ether 
• 94994-00-0 methyl 4-iodobicyclo<2.2.2>octane-1-carboxylate 
• 18720-35-9 bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester 
• 1659-75-2 Bicyclo<2.2.2.>octan-1,4-dicarbonsauere-ethylester 
• 834-50-4 4-(ethoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid 
• 843-59-4 Diethyl 2,5-Dioxobicyclo<2.2.2>octane-1,4-dicarboxylate 
• 1686-98-2 2,5-Bis-ethylendimercapto-bicyclo<2,2,2>octan-1,4-dicarbonsaeure-diethylester 
• 1299425-88-9 ethyl 4-iodobicyclo[2.2.2]octane-1-carboxylate 
• 787-07-5 diethyl 1,4-cyclohexanedione-2,5-dicarboxylate 

Downstream Products

• 94994-00-0 methyl 4-iodobicyclo<2.2.2>octane-1-carboxylate 
• 1299426-08-6 4-iodo-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide 
• 905457-33-2 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide 
• 94994-06-6 4-chlorobicyclo<2.2.2>octane-1-carbonyl fluoride 

Relevant academic research and scientific papers

BRIDGED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor

Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N -{2-[4-(2-methoxyphenyl)piperazin-1-yl] ethyl}- N -(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor

Here we describe the design, synthesis, and pharmacological profile of 5-HT1A receptor ligands related to 1 (WAY-100635). The cyclohexyl moiety in 1 and its O-desmethylated analogue 3 were replaced by the bridgehead iodinated bridge-fused rings: adamantyl, cubyl, bicyclo[2.2.2]octyl, or bicyclo[2.2.1]heptyl. All analogues displayed a (sub)nanomolar affinity for the 5-HT1A receptor in vitro. Compounds 6b and 7b appeared to be selective for this receptor over other relevant receptors and could easily be iodinated with radioactive iodine-123. In humane hepatocytes, [ 123I]6b showed a low propensity for amide hydrolysis and a stable carbon-iodine bond. The biodistribution of [123I]6b and [ 123I]7b in rats revealed that the carbon-iodine bond was also stable in vivo. Unfortunately, the brain uptake and the specificity for both radioligands were significantly lower than those of the parent molecule 1. In conclusion, the designed tracers are not suitable for SPECT imaging.

Polar Substituent Effects on 19F Chemical Shifts of Aryl and Vinyl Fluorides: A Fluorine-19 Nuclear Magnetic Resonance Study of Some 1,1-Difluoro-2-(4-substituted-bicyclooct-1-yl)ethenes

An extensive series of 1,1-difluoro-2-(4-substituted-bicyclooct-1-yl)ethenes (2) covering a diverse range of substituents ( X = H, NO2, CN, CF3, COOCH3, F, Cl, Br, OCH3, C6H5, C2H, C2Si(CH3)3, CH3, and C(CH3)3) have been synthesized and their 19F N

Substituent Effects on Electroreduction of the Carbon-Halogen Bond

Polarographic reduction of a series of 4-substituted 1-iodobicyclooctanes has been examined in an attempt to assess the effect of substituents on the half-wave reduction potential.It is found that the values of E1/2 do not show a linear correlation with the relevant ?I constants; the deviations are discussed in terms of the relative importance of the steric and electric field effects of the substituent.Controlled-potential electrolysis of a number of the substrates reveals that the hydrocarbon corresponding to fission of the carbon-iodine bond is formed in high yield.