80749-35-5Relevant academic research and scientific papers
Cobalt-Catalyzed Hydrogenative Transformation of Nitriles
Zhang, Shaoke,Duan, Ya-Nan,Qian, Yu,Tang, Wenyue,Zhang, Runtong,Wen, Jialin,Zhang, Xumu
, p. 13761 - 13767 (2021/11/17)
Here, we report the transformation of nitrile compounds in a hydrogen atmosphere. Catalyzed by a cobalt/tetraphosphine complex, hydrogenative coupling of unprotected indoles with nitriles proceeds smoothly in a basic medium, yielding C3 alkylated indoles. In addition, the direct hydrogenation of nitriles under the same conditions yielded primary amines. Isotope labeling experiments, along with a series of control experiments, revealed a reaction pathway that involves nucleophilic addition of indoles and 1,4-reduction of a conjugate imine intermediate. Different from reductive alkylation of indoles under an acidic condition, E1cB elimination is believed to occur in this base-promoted hydrogenative coupling reaction.
An efficient route to 2,3-disubstituted indoles via reductive alkylation using H2 as reductant
Cao, Liang-Liang,Wang, Duo-Sheng,Jiang, Guo-Fang,Zhou, Yong-Gui
supporting information; experimental part, p. 2837 - 2839 (2011/06/21)
An efficient route to 2,3-disubstituted indoles was developed via reductive alkylation of 2-substituted indoles using hydrogen as a clean and atom economic reductant under ambient pressure.
The Reduction of Some Alicyclic- and Aryl-substituted 3-Acyl Derivatives of 2-Methylindole
Clark, Brian J.,Grayshan, Roder,Miller, David D.
, p. 2237 - 2240 (2007/10/02)
The structure of the products formed fro the reduction of some 3-acyl derivatives of 2-methylindole were dependent on the nature of the substituent α-to the carbonyl group and the reducing agent being used.When the substituent was aryl the only recoverabl
