80749-40-2

Upstream product

• 104-82-5 4-Methylbenzyl chloride 
• 1885-29-6 anthranilic acid nitrile 
• 124643-45-4 2-(p-tolylethynyl)aniline 
• 80749-35-5 2-methyl-3-(4-tolylmethyl)indole 
• 874-60-2 4-methyl-benzoyl chloride 
• 26211-87-0 3-(4-methylbenzoyl)-2-methyl-1H-indole 
• 95-20-5 2-methyl-1H-indole 
• 80749-37-7 2-acetamidophenyl 4-tolylmethyl ketone 

Downstream Products

• 80749-44-6 2-azidophenyl 4-tolylmethyl ketone 
• 80749-51-5 2-amino-3-(4-tolylmethyl)indazole 
• 80749-47-9 3-(4-methylbenzyl)-1H-indazole 

Relevant academic research and scientific papers

PtO2/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups

A highly efficient PtO2/PTSA catalyst system for the hydration of a wide array of alkynes was developed. This method proved to be compatible with a large range of functional groups and the ketone products were obtained in high yields. The scope of this methodology was also extended to the synthesis of 3-Aryl-isochromenones,-indoles and-benzofurans.

One-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene

Herein, we describe the iron(III)-catalyzed oxidative coupling of alcohol/methyl arene with 2-amino phenyl ketone to synthesize 4-quinolone. Alcohols and methyl arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-butyl peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.