80756-85-0

Basic information

• Product Name: S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate
• Synonyms: S-2-BENZOTHIAZOYL-2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLEACETATE;S-2-BENZATHIAZOYL-2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLACETAT;(2-mercaptobenzothiazolyl)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate(syn;2-(2-amino-4-thiazole)-2-methoxyiminoacetic,thiobenzothiazoleester;2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic,thiobenzothiazoleester;2-amino-alpha-(methoxyimino)-4-thiazoleethanethioicacis-2-benzothiazolyl;s-2-benzothiazolyl(z)-2-amino-alpha-(methoxyimino)-4-thiazoleethanethioate;s-benzothiazol-2-yl(z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)thioacet
• CAS NO: 80756-85-0
• Molecular Formula: C₁₃H₁₀N₄O₂S₃
• Molecular Weight: 350.44
• EINECS: 279-540-6
• Product Categories: Cephalosporins;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 80756-85-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 128-130 °C(lit.)
• Boiling Point: 563.2 °C at 760 mmHg
• Flash Point: 294.4 °C
• Appearance: light yellow powder
• Density: 1.63
• Vapor Pressure: 1.04E-12mmHg at 25°C
• Refractive Index: 1.6200 (estimate)
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 1.22±0.10(Predicted)
• Stability: Moisture Sensitive
• CAS DataBase Reference: S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate(CAS DataBase Reference)
• NIST Chemistry Reference: S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate(80756-85-0)
• EPA Substance Registry System: S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate(80756-85-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 2
• RTECS: XJ4664500
• Hazardous Substances Data: 80756-85-0(Hazardous Substances Data)

Usage

Chemical Properties

S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate is light yellow powder

Uses

S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate is used in the synthesis of Cefotaxime and related derivatives, such as: Ceftriaxone (C245000).

Hazard

Low toxicity by ingestion.

InChI:InChI=1/C13H10N4O2S3/c1-19-17-10(8-6-20-12(14)15-8)11(18)22-13-16-7-4-2-3-5-9(7)21-13/h2-6H,1H3,(H2,14,15)/b17-10-

Synthetic route

2,3-cyclopentenopyridine (533-37-9) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 7-Aminocephalosporanic acid (957-68-6) → cefpirome Sulfate (98753-19-6)

Conditions	Yield
With sulfuric acid for 0.0666667h; Time; Microwave irradiation;	99%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 7-aminodesacetoxycephalosporanic acid (26395-99-3) → (Z)-7-[(2-amino-4-thiazolyl-2-methoxyiminoacetylamino)]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (65052-63-3, 65052-69-9)

Conditions	Yield
With dmap; triethylamine In water; acetone at 20℃; for 3.5h; Time;	98.5%

(6R,7R)-7-amino-3-[(1-methyl-1-pyrrolidinyl)methyl]-3-cephem-4-carboxylic acid + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → Cefepime dihydrochloride

Conditions	Yield
With sulphurous acid; triethylamine In dichloromethane at 0 - 5℃; Concentration; Large scale;	98.3%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → di(benzothiazol-2-yl)disulfide (120-78-5)

Conditions	Yield
With tetrabutylammomium bromide; ozone In methanol at 44℃; for 1.5h; Concentration; Temperature; Large scale;	97.5%

sulphapyridine (144-83-2) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)-N-(4-(N-(pyridin-2-yl)sulfamoyl)phenyl)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	96%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 7-aminoceftrizine (58909-56-1) → ceftriaxone disodium (74578-69-1)

Conditions	Yield
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-aminoceftrizine With triethylamine In methanol at -2 - 3℃; Stage #2: With sodium 2-ethylhexanoic acid In water; isopropyl alcohol at 26 - 30℃; for 2h; Product distribution / selectivity;	95.5%
With sodium metabisulfite; edetate disodium; triethylamine In ethanol; water at 1 - 3℃; for 3h; Time;	91%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 7-Aminocephalosporanic acid (957-68-6) → cefotaxime (63527-52-6)

Conditions	Yield
With TEA In dichloromethane at 20℃; for 1h; Substitution;	95%
With triethylamine In dichloromethane at 20℃; for 1h;	95%
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-Aminocephalosporanic acid With triethylamine In methanol at 0 - 5℃; Stage #2: With hydrogenchloride In methanol; water at 0 - 5℃; for 1h; pH=2.3 - 2.5;
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-Aminocephalosporanic acid With triethylamine In 1,2-dimethoxyethane at -5 - 0℃; Stage #2: With hydrogenchloride In 1,2-dimethoxyethane; water for 1h; pH=2.6 - 2.8; Product distribution / selectivity;

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 7-aminoceph-3-em-4-carboxylic acid ester (36923-17-8) → ceftizoxime acid

Conditions	Yield
With diethylamine In dichloromethane; butan-1-ol at -5℃; for 12h; Solvent; Reagent/catalyst; Autoclave; Large scale;	93.6%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid (70458-96-7) → 1-ethyl-6-fluoro-7-(1-(4-((Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetyl)piperazinyl))-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Conditions	Yield
With triethylamine In ethanol at 20 - 25℃; Schotten-Baumann reaction;	93%

(6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (155723-02-7) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + diisopropylamine (108-18-9) → C19H18N6O5S3*C6H15N

Conditions	Yield
Stage #1: (6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With dmap; triethylamine In dichloromethane at 0 - 15℃; Darkness; Stage #2: diisopropylamine In dichloromethane; water; ethyl acetate	92.8%

7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → potassium (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(Z)-2-(4-methylthiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Conditions	Yield
Stage #1: 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With triethylamine In tetrahydrofuran; water at 0 - 5℃; for 2.25 - 3.33333h; Stage #2: With potassium acetate In tetrahydrofuran; water; acetone at 20 - 25℃;	89%

7-MPCA + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → cefepime Hydrochloride + 2-Mercaptobenzothiazole (149-30-4)

Conditions	Yield
Stage #1: 7-MPCA With triethylamine In dichloromethane for 0.5h; Stage #2: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate In dichloromethane at 25 - 28℃; for 2h; Temperature;	A 89% B n/a

ciprofloxacin (85721-33-1) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → 1-cyclopropyl-6-fluoro-7-(1-(4-((Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetyl)piperazinyl))-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Conditions	Yield
With triethylamine In ethanol at 20 - 25℃; Schotten-Baumann reaction;	88%

C13H13N3O2S2 + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → cefditoren (104145-95-1)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 5℃; for 4h;	85%

sulfadimethoxine (122-11-2) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → (Z)-2-(2-aminothiazol-4-yl)-N-(4-(N-(2,6-dimethoxypyrimidin-4-yl)sulfamoyl)phenyl)-2-(methoxyimino)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	84.6%

(6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (155723-02-7) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → 7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt (104146-53-4)

Conditions	Yield
Stage #1: (6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With sulphurous acid; triethylamine In methanol; dichloromethane at 0 - 5℃; for 4h; Darkness; Stage #2: With (+/-)-2-n-ethylpentanoic acid sodium salt In water; acetone at 20 - 25℃; for 2h; Temperature;	83.9%
Stage #1: (6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With dmap; triethylamine In dichloromethane at 0 - 15℃; Darkness; Stage #2: With sodium isooctanoate In water; acetone	82%

sulfisoxazole (127-69-5) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → (Z)-2-(2-aminothiazol-4-yl)-N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-2-(methoxyimino)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	83.1%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (24701-69-7) → cefpodoxime (80210-62-4)

Conditions	Yield
With triethylamine In tetrahydrofuran at -5 - 5℃; for 2h;	82.86%
With triethylamine In tetrahydrofuran at 0 - 5℃; for 2h;	82.86%
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In methanol at 8 - 12℃; Stage #2: With sulfuric acid In methanol; water at 0 - 20℃; pH=2.4 - 2.5; Product distribution / selectivity;
With triethylamine In methanol; water at 15 - 20℃;	81 mg

(6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (155723-02-7) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → lithium (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(Z)-2-(4-methylthiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Conditions	Yield
Stage #1: (6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With triethylamine In dichloromethane at 0℃; Stage #2: With lithium tert-butoxide In dichloromethane; acetone for 1h;	82.1%

7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → 7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt (104146-53-4)

Conditions	Yield
Stage #1: 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With triethylamine In tetrahydrofuran; water at 0 - 5℃; for 2.25 - 3.33333h; Stage #2: With sodium 2-ethylhexanoic acid In tetrahydrofuran; water; acetone at 20 - 25℃;	75%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + sulfameter (651-06-9) → (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)-N-(4-(N-(5-methoxypyrimidin-2-yl)sulfamoyl)phenyl)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	73.7%

1-[((6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methylpyrrolidinium chloride hydrochloride (113703-50-7) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → Cefepime dihydrochloride

Conditions	Yield
Stage #1: 1-[((6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methylpyrrolidinium chloride hydrochloride; (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With triethylamine In water; N,N-dimethyl-formamide at 20℃; for 3h; pH=7; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide Solvent; Reagent/catalyst;	73%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + sarafloxacin (98105-99-8) → 1-(4-fluorobenzyl)-6-fluoro-7-(1-(4-((Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetyl)piperazinyl))-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Conditions	Yield
With triethylamine In ethanol at 20 - 25℃; Schotten-Baumann reaction;	72%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + sulfamethoxazole (91687-52-4) → (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)-N-(4-(N-(4-methyloxazol-2-yl)sulfamoyl)phenyl)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	70.7%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 4-(2-aminoethyl)benzenesulfonamide (35303-76-5) → (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)-N-(4-sulfamoylphenethyl)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	65%

sulfabenzamide (127-71-9) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → (Z)-N-((4-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)phenyl)sulfonyl)benzamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	65%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + 1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene (57-67-0) → (Z)-2-(2-aminothiazol-4-yl)-N-(4-(N-carbamimidoylsulfamoyl)phenyl)-2-(methoxyimino)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	64.7%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + sulfanilamide (63-74-1) → (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)-N-(4-sulfamoylphenyl)acetamide

Conditions	Yield
With triethylamine In ethanol at 20℃; Inert atmosphere;	63.8%

4-homosulfanilamide (138-39-6) + (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) → (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)-N-(4-sulfamoylbenzyl)acetamide

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	61.5%

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + (6R-trans)-7-amino-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid trifluoroacetic acid salt (135327-68-3) → <6R-<6α,7β-(Z)>>-7-<<(2-amino-4-thiazolyl)(methoxyimino)acetyl>amino>-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid (135312-05-9)

Conditions	Yield
With potassium hydrogencarbonate In tetrahydrofuran; water Ambient temperature;	59.8%

Downstream Products

• 63527-52-6 cefotaxime 
• 73384-59-5 ceftriaxone 
• 120-78-5 di(benzothiazol-2-yl)disulfide 
• 149-30-4 2-Mercaptobenzothiazole 
• 104146-53-4 7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt 
• 98753-19-6 cefpirome Sulfate 
• 74578-69-1 ceftriaxone disodium 
• 73384-59-5 Ceftriaxone 
• 65243-25-6 sodium 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-methyl-ceph-3-em-4-carboxylic acid 
• 65052-63-3 cefetamet 
• 139263-65-3 <6R<6α,7β(Z)>>-3-(acetoxymethyl)-7-<(methoxyimino)<2-(triphenylmethyl)amino-4-thiazolyl>acetylamino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid (1:1) triethylamine salt 
• 64486-19-7 7β-[2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid 
• 87239-81-4 cefpodoxime proxetil 
• 60846-23-3 cefotaxime sodium salt