807610-78-2Relevant academic research and scientific papers
Organocatalyzed solvent-free Aza-Henry reaction: A breakthrough in the one-pot synthesis of 1,2-diamines
Bernardi, Luca,Bonini, Bianca F.,Capito, Elena,Dessole, Gabriella,Comes-Franchini, Mauro,Fochi, Mariafrancesca,Ricci, Alfredo
, p. 8168 - 8171 (2004)
A nitrogen-containing superbase such as TMG was found to be an effective catalyst for the reaction between N-diphenylphosphinoyl imines and nitroalkanes. Exploiting a protocol that avoids the use of any solvent also during workup procedure, we synthesized
Electrochemically induced aza-Henry reaction: A new, mild, and clean synthesis of α-nitroamines
Rossi, Leucio,Bianchi, Gabriele,Feroci, Marta,Inesi, Achille
, p. 2505 - 2508 (2007)
The addition reaction of nitro compounds to azomethine functions, known as the aza-Henry (or nitro-Mannich) reaction was performed electrochemically under solvent and supporting electrolyte-free conditions. Reaction yields are very good and the method is
ASYMMETRIC MICHAEL AND ALDOL ADDITION USING BIFUNCTIONAL CINCHONA-ALKALOID-BASED CATALYSTS
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Page/Page column 8/25, (2008/06/13)
One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with 5 base and a compound that has a suitable leaving group, and 2) converting the ring methoxy group to a hydroxy group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone, comprising the step of: reacting a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral 10 ketone with a nucleophile in the presence of a catalyst; thereby producing a chiral, non racemic compound; wherein said catalyst is a derivatized quinine or quinidine. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of reacting racemic chiral alkene with a nucleophile in the presence of a derivatized quinine or quinidine.
The first catalytic asymmetric nitro-Mannich-type reaction promoted by a new heterobimetallic complex
Yamada, Ken-Ichi,Harwood, Simon J.,Groeger, Harald,Shibasaki, Masakatsu
, p. 3504 - 3506 (2007/10/03)
The best ratio is 1:1:3 for the components Yb, K, and binaphthol in the new heterobimetallic complex, which efficiently catalyzes an asymmetric nitro-Mannich-type reaction. The desired nitro-Mannich products 2 are obtained with up to 91% ee starting from
