807614-69-3

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 253453-91-7 2-chloro-1-methyl-1H-imidazole 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 

Downstream Products

• 1600565-91-0 (2-chloro-1-methyl-1H-imidazol-5-yl)(4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)methanol 
• 465615-69-4 (4-chlorophenyl)-[2-(1-isopropylpiperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]methanone 
• 869002-72-2 (4-chlorophenyl)-{2-[(1-isopropylpiperidin-4-ylmethyl)amino]-3-methyl-3H-imidazol-4-yl}methanone 

Relevant academic research and scientific papers

Scalable synthesis of imidazole derivatives

Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.

A scalable synthesis of a histamine H3 receptor antagonist

Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane.