80762-32-9

Upstream product

• 21423-81-4 3-chloro-4-methylbenzonitrile 
• 21924-83-4 4-(bromomethyl)-3-chlorobenzonitrile 
• 80762-31-8 diethyl 2-(2-chloro-4-cyanobenzyl)malonate 

Downstream Products

• 80762-35-2 3'-chloro-4'-(3-hydroxypropyl)propiophenone 
• 80762-34-1 3-chloro-4-(3-hydroxypropyl)benzonitrile 
• 80762-36-3 α-bromo-3-chloro-4-(3-hydroxypropyl)propiophenone 
• 80762-33-0 3-(2-chloro-4-cyanophenyl)propanoic acid 

Relevant academic research and scientific papers

Design and synthesis of a hapten for the radioimmunoassay of bupropion

The synthesis of a hapten useful in the radioimmunoassay of bupropion is described. Since bupropion has no functional group that can be easily derivatized, a hydroxypropyl group was incorporated into the molecule. Studies in cross-reactivity with possible metabolites required the synthesis of the 4'-hydroxy analogue of bupropion. This synthesis is also described.

Compounds and methods of making same

A radioimmunoassay procedure has been discovered for bupropion [(±)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula STR1 wherein either R2 is oxygen and R1 is (CHsu