807628-23-5

Upstream product

• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 247149-96-8 5-amino-3-(4-methoxy-phenyl)-2H-indeno[1,2-c]pyrazol-4-one 

Downstream Products

• 360792-99-0 [3-(4-methoxy-phenyl)-4-oxo-2-(2-trimethylsilanyl-ethoxymethyl)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-carbamic acid phenyl ester 
• 807628-29-1 C₃₄H₃₉N₅O₈Si 
• 807628-35-9 C₃₁H₃₅N₇O₅Si 
• 807628-31-5 C₃₁H₃₄N₆O₆Si 
• 807628-34-8 C₃₁H₃₃N₅O₇Si 
• 807628-25-7 C₃₃H₃₇N₅O₆Si 
• 807628-45-1 C₃₃H₃₇N₅O₇Si 
• 807628-49-5 C₃₁H₃₃N₅O₇Si 
• 807628-33-7 C₃₁H₃₁Cl₂N₅O₅Si 
• 807628-38-2 C₃₅H₃₅N₅O₅Si 
• 807628-43-9 C₃₅H₃₅N₅O₅Si 
• 807628-53-1 C₃₁H₃₄N₆O₅Si 
• 807628-27-9 C₃₁H₃₂N₆O₇Si 
• 807628-54-2 C₃₁H₃₄N₆O₅Si 

Relevant academic research and scientific papers

Parallel synthesis of acylsemicarbazide libraries: Preparation of potent cyclin dependent kinase (cdk) inhibitors

Potent cyclin dependent kinase inhibitors were prepared using parallel synthesis methodology. Treating advanced intermediate 2 with a variety of hydrazides in DMSO at 80°C for 30 min gave the desired acylsemicarbazides in good to excellent yield. Several compounds were active against cdk4/D1 and cdk2/E in the low nanomolar range. The SAR indicates a wide variety of substituents are tolerated at the acylsemicarbazide moiety. Potent cyclin dependent kinase inhibitors were prepared using parallel synthesis methodology. Treating advanced intermediate 2 with a variety of hydrazides in DMSO at 80°C for 30 min gave the desired acylsemicarbazides in good to excellent yield. Several compounds were active against cdk4/D1 and cdk2/E in the low nanomolar range. The SAR indicates a wide variety of substituents are tolerated at the acylsemicarbazide moiety.