360792-99-0

Basic information

• Product Name: Carbamic acid, [2,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-[[2-(trimethylsilyl)ethoxy]meth yl]indeno[1,2-c]pyrazol-5-yl]-, phenyl ester
• CAS NO: 360792-99-0
• Molecular Formula: C30H31N3O5Si
• Molecular Weight: 541.679
• Mol File: 360792-99-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-[[2-(trimethylsilyl)ethoxy]meth yl]indeno[1,2-c]pyrazol-5-yl]-, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-[[2-(trimethylsilyl)ethoxy]meth yl]indeno[1,2-c]pyrazol-5-yl]-, phenyl ester(360792-99-0)
• EPA Substance Registry System: Carbamic acid, [2,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-[[2-(trimethylsilyl)ethoxy]meth yl]indeno[1,2-c]pyrazol-5-yl]-, phenyl ester(360792-99-0)

Safety Data

• Hazardous Substances Data: 360792-99-0(Hazardous Substances Data)

Upstream product

• 247149-96-8 5-amino-3-(4-methoxy-phenyl)-2H-indeno[1,2-c]pyrazol-4-one 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 1885-14-9 phenyl chloroformate 
• 807628-23-5 5-amino-3-(4-methoxy-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-indeno[1,2-c]pyrazol-4-one 

Downstream Products

• 807628-41-7 C₃₂H₃₅N₅O₅Si 

Relevant articles and documents

Parallel synthesis of acylsemicarbazide libraries: Preparation of potent cyclin dependent kinase (cdk) inhibitors

Potent cyclin dependent kinase inhibitors were prepared using parallel synthesis methodology. Treating advanced intermediate 2 with a variety of hydrazides in DMSO at 80°C for 30 min gave the desired acylsemicarbazides in good to excellent yield. Several compounds were active against cdk4/D1 and cdk2/E in the low nanomolar range. The SAR indicates a wide variety of substituents are tolerated at the acylsemicarbazide moiety. Potent cyclin dependent kinase inhibitors were prepared using parallel synthesis methodology. Treating advanced intermediate 2 with a variety of hydrazides in DMSO at 80°C for 30 min gave the desired acylsemicarbazides in good to excellent yield. Several compounds were active against cdk4/D1 and cdk2/E in the low nanomolar range. The SAR indicates a wide variety of substituents are tolerated at the acylsemicarbazide moiety.